Lenangio 10mg Capsule

About

Lenalidomide is an immunomodulatory drug (IMiD) with anti-angiogenic, anti-neoplastic, and immunomodulatory properties. It is primarily used in the treatment of certain hematological malignancies. Its mechanism involves direct tumoricidal effects, inhibition of angiogenesis, and modulation of the immune system. Specifically, it enhances T-cell and natural killer (NK) cell activity, inhibits pro-inflammatory cytokine production, and induces apoptosis in malignant cells. This multifaceted action makes it effective in managing conditions characterized by abnormal cell proliferation and immune dysregulation. It is often used in combination with other agents to maximize therapeutic efficacy and overcome resistance mechanisms, improving patient outcomes in complex disease settings.

Uses

• Multiple Myeloma
• Myelodysplastic Syndromes (MDS) with del(5q)
• Mantle Cell Lymphoma (MCL)
• Follicular Lymphoma

Directions For Use

Take this capsule orally with water, generally at the same time each day, with or without food, as directed by your physician. Do not open, break, or chew the capsule.

Benefits

• Effective in treating specific blood cancers.
• Improves overall survival in multiple myeloma.
• Reduces transfusion dependence in certain MDS patients.
• Offers a targeted approach to cancer therapy.
• Can be used in combination regimens for enhanced efficacy.
• Helps to control disease progression and symptoms.

Side Effects

• Fatigue
• Diarrhea
• Constipation
• Nausea
• Rash
• Peripheral neuropathy
• Thrombocytopenia
• Neutropenia
• Deep vein thrombosis (DVT)
• Pulmonary embolism (PE)
• Muscle cramps
• Dizziness

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects like dizziness or fatigue, and potentially interact with the medication.
• Pregnancy - Lenalidomide is highly teratogenic and absolutely contraindicated in pregnancy. Strict contraception is required for both male and female patients.
• Breastfeeding - Not recommended during breastfeeding due to the potential for serious adverse effects in the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary, and liver function should be monitored regularly.
• Kidney - Dose adjustments are typically required for patients with renal impairment, and kidney function should be closely monitored.
• Lung - Monitor for new or worsening pulmonary symptoms, as interstitial lung disease or pulmonary hypertension can occur rarely.

Disclaimer

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