Lengis 4mg Capsule

About

Lengis 4mg Capsule, likely containing lenvatinib, is a targeted anti-cancer medication that functions as a multi-kinase inhibitor. It specifically targets and blocks the activity of several receptor tyrosine kinases, including VEGFR1-3, FGFR1-4, PDGFRα, KIT, and RET. By inhibiting these crucial signaling pathways, Lengis disrupts tumor angiogenesis, which is the formation of new blood vessels essential for tumor growth, and directly inhibits tumor cell proliferation and survival. This comprehensive mechanism of action makes it an effective treatment option for various advanced malignancies where these pathways are implicated, helping to control disease progression and improve patient outcomes.

Uses

• Treatment of differentiated thyroid cancer (DTC) refractory to radioactive iodine.
• Management of advanced renal cell carcinoma (RCC) in combination with everolimus.
• First-line treatment for unresectable hepatocellular carcinoma (HCC).
• Treatment of advanced endometrial carcinoma in combination with pembrolizumab.

Directions For Use

Take orally once daily with or without food, at approximately the same time each day. Swallow the capsule whole.

Benefits

• Inhibits multiple key oncogenic pathways.
• Effective against various advanced solid tumors.
• Helps to control tumor progression.
• Offers a targeted approach to cancer therapy.
• Convenient oral administration.
• Can improve progression-free survival.

Side Effects

• Hypertension (high blood pressure)
• Fatigue and asthenia
• Diarrhea
• Decreased appetite
• Weight loss
• Nausea and vomiting
• Proteinuria (protein in urine)
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Hypothyroidism
• Headache
• Dysphonia (hoarseness)
• Abdominal pain

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it may exacerbate liver-related side effects or interact with the medication.
• Pregnancy - Contraindicated during pregnancy due to potential fetal harm. Women of childbearing potential must use effective contraception.
• Breastfeeding - Breastfeeding is not recommended during treatment and for at least one week after the last dose due to potential harm to the infant.
• Liver - Use with caution and dose adjustment may be required in patients with moderate to severe hepatic impairment.
• Kidney - Dose adjustment may be necessary for patients with severe renal impairment. Monitor renal function regularly.
• Lung - Monitor for signs of pulmonary embolism or interstitial lung disease, though these are rare.

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