Lentris 10mg Capsule

About

Lentris 10mg Capsule contains Lenvatinib, an oral multi-kinase inhibitor indicated for the treatment of various cancers. It functions by selectively inhibiting the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1, VEGFR2, and VEGFR3, in addition to fibroblast growth factor (FGF) receptors FGFR1, FGFR2, FGFR3, and FGFR4. It also targets other proangiogenic and oncogenic signaling pathways associated with platelet-derived growth factor receptor alpha (PDGFRα), KIT, and RET proto-oncogene. This targeted action helps to reduce tumor growth and angiogenesis, which is the formation of new blood vessels that supply tumors.

This medication is a crucial component in the management of advanced or metastatic cancers where these pathways are implicated. Its mechanism of action targets multiple pathways involved in tumor proliferation and survival, making it an effective therapeutic option for patients who have progressed on other treatments or for whom standard therapies are not suitable. Regular monitoring for efficacy and side effects is essential throughout the treatment course to optimize patient outcomes.

Uses

• Treatment of differentiated thyroid cancer (DTC) that is refractory to radioactive iodine.
• Management of unresectable hepatocellular carcinoma (HCC).
• Used in combination with everolimus for advanced renal cell carcinoma (RCC) after one prior anti-angiogenic therapy.
• Used in combination with pembrolizumab for advanced endometrial carcinoma that is not microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR).

Directions For Use

Take this capsule orally once daily, with or without food, as directed by your physician. Swallow the capsule whole; do not open or crush it.

Benefits

• Targets multiple pathways involved in cancer growth.
• Effective in various advanced or metastatic cancers.
• Offers an oral treatment option for patients.
• Can improve progression-free survival in certain indications.
• Provides a targeted therapy approach.
• May be used in combination with other agents for enhanced efficacy.

Side Effects

• Hypertension
• Fatigue
• Diarrhea
• Arthralgia/Myalgia
• Decreased appetite
• Weight loss
• Nausea
• Proteinuria
• Palmar-plantar erythrodysesthesia syndrome
• Dysphonia
• Hypothyroidism
• Hemorrhage

Safety Measures

• Alcohol - It is generally advisable to limit or avoid alcohol consumption while on this medication, as it may exacerbate potential liver side effects or interact with drug metabolism.
• Pregnancy - This medication is contraindicated during pregnancy due to potential fetal harm. Effective contraception must be used by women of reproductive potential during treatment and for at least one month after the last dose.
• Breastfeeding - Breastfeeding is not recommended during treatment and for at least one month after the last dose, as it is unknown if the drug is excreted in human milk and could cause serious adverse reactions in a breastfed infant.
• Liver - Use with caution in patients with hepatic impairment. Dose adjustments may be necessary, and liver function should be closely monitored throughout treatment.
• Kidney - Caution is advised in patients with renal impairment. Dose modifications may be required based on the degree of kidney dysfunction, and renal function should be regularly assessed.
• Lung - Monitor for signs and symptoms of pulmonary toxicity, such as pneumonitis or interstitial lung disease. Promptly report any new or worsening respiratory symptoms to your doctor.

Disclaimer

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