Letoval 2.5mg Tablet

About

Letoval 2.5mg Tablet is an aromatase inhibitor primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It works by potently and selectively inhibiting the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues. By significantly reducing estrogen levels, Letoval deprives estrogen-dependent breast cancer cells of the growth stimulus they require, thereby slowing or stopping tumor progression. This oral medication is a crucial component of adjuvant therapy, extended adjuvant therapy, and first-line treatment for metastatic disease, offering a targeted approach to hormone-sensitive cancers.

Uses

• Adjuvant treatment of early breast cancer in postmenopausal women.
• Extended adjuvant treatment of early breast cancer.
• First-line treatment of advanced breast cancer in postmenopausal women.
• Treatment of advanced breast cancer after antiestrogen therapy failure.

Directions For Use

Take Letoval 2.5mg Tablet orally once daily, with or without food, at approximately the same time each day.

Benefits

• Significantly reduces estrogen levels.
• Inhibits growth of hormone-sensitive tumors.
• Effective in early and advanced breast cancer.
• Oral, once-daily administration.
• Improves disease-free survival.
• Well-established efficacy in postmenopausal women.

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Fatigue
• Nausea
• Headache
• Dizziness
• Bone pain
• Osteoporosis
• Hair thinning
• Weight gain
• Peripheral edema
• Vaginal dryness

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake may exacerbate hot flashes or other side effects.
• Pregnancy - Letoval is contraindicated in pregnancy due to potential for fetal harm. It is for postmenopausal women, but contraception is advised if there's any doubt.
• Breastfeeding - Not applicable as Letoval is for postmenopausal women. If used in premenopausal women, breastfeeding is contraindicated.
• Liver - Use with caution in patients with severe hepatic impairment; dose adjustments may be necessary. Monitor liver function periodically.
• Kidney - No dose adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment.
• Lung - No specific lung-related safety concerns are typically associated with Letoval. Monitor for any new or worsening respiratory symptoms.

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