Letpro 2.5mg Tablet

About

Letrozole is a potent, highly selective, non-steroidal aromatase inhibitor, primarily used in the management of hormone receptor-positive breast cancer in postmenopausal women. Its mechanism of action involves blocking the enzyme aromatase, which is crucial for the peripheral conversion of androgens into estrogens. In postmenopausal individuals, this enzymatic pathway is the primary source of estrogen production. By significantly reducing systemic estrogen levels, letrozole effectively inhibits the growth and proliferation of estrogen-dependent breast cancer cells. This targeted approach makes it a cornerstone in both the adjuvant treatment of early-stage breast cancer, aiming to prevent recurrence, and in the treatment of advanced or metastatic disease. Its efficacy in suppressing estrogen-driven tumor growth has established it as a vital therapeutic agent in oncology, offering a significant advantage in improving patient outcomes and disease-free survival.

Uses

• Adjuvant treatment of early hormone receptor-positive breast cancer in postmenopausal women.
• Extended adjuvant treatment of hormone receptor-positive breast cancer in postmenopausal women who have completed standard tamoxifen therapy.
• First-line treatment of hormone receptor-positive advanced breast cancer in postmenopausal women.
• Treatment of advanced breast cancer in postmenopausal women after antiestrogen therapy.

Directions For Use

Take orally once daily, with or without food, as directed by your physician.

Benefits

• Significantly reduces recurrence risk in early breast cancer.
• Effective in treating advanced hormone-sensitive breast cancer.
• Improves disease-free survival in postmenopausal women.
• Offers a non-steroidal option for estrogen suppression.
• Can be used as extended adjuvant therapy.
• Generally well-tolerated with a predictable side effect profile.

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Fatigue
• Nausea
• Headache
• Dizziness
• Bone pain
• Muscle pain (myalgia)
• Increased sweating
• Hair thinning
• Weight gain
• Osteoporosis

Safety Measures

• Alcohol - Alcohol consumption should be moderate as it may exacerbate certain side effects like dizziness or fatigue.
• Pregnancy - Absolutely contraindicated in pregnancy due to potential for fetal harm; effective contraception is essential for premenopausal women.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if letrozole is excreted in human milk and could harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustment may be necessary for severe liver dysfunction.
• Kidney - Generally safe for use in patients with mild to moderate renal impairment; no dose adjustment typically required.
• Lung - No specific precautions for lung conditions, but monitor for any new or worsening respiratory symptoms.

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