About
Letrozole is a potent and highly selective non-steroidal aromatase inhibitor. It works by competitively binding to the heme of the cytochrome P450 subunit of aromatase, an enzyme primarily responsible for converting androgens into estrogens in peripheral tissues. By inhibiting aromatase, letrozole significantly reduces circulating estrogen levels in postmenopausal women, thereby depriving estrogen-dependent breast cancer cells of the growth stimulus they require. This mechanism makes it a highly effective treatment for hormone receptor-positive breast cancer, particularly in the adjuvant setting after surgery, as extended adjuvant therapy, or for advanced disease. Its efficacy stems from its ability to achieve profound estrogen suppression, which is crucial for controlling the proliferation of estrogen-sensitive tumors.
Uses
- Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women.
- Extended adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women who have received prior standard adjuvant tamoxifen therapy.
- First-line treatment of hormone receptor-positive or unknown advanced breast cancer in postmenopausal women.
- Treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.
Directions For Use
Take this tablet orally, usually once daily, with or without food, as directed by your doctor. Do not crush or chew the tablet.
Benefits
- Significantly reduces estrogen levels.
- Effective in treating hormone-sensitive breast cancer.
- Reduces risk of breast cancer recurrence.
- Improves disease-free survival.
- Well-tolerated in many patients.
- Offers a non-steroidal treatment option.
Side Effects
- Hot flashes
- Joint pain (arthralgia)
- Fatigue
- Nausea
- Headache
- Dizziness
- Bone pain
- Osteoporosis
- Hair thinning
- Weight gain
- Vaginal bleeding (rare)
- Cholesterol elevation
Safety Measures
- Alcohol - No specific interaction with alcohol is known, but it's generally advisable to limit alcohol intake during treatment.
- Pregnancy - Letrozole is contraindicated in pregnant women due to potential harm to the fetus. Effective contraception must be used by premenopausal women.
- Breastfeeding - It is unknown if letrozole is excreted in human milk. Due to the potential for serious adverse reactions in breastfed infants, breastfeeding is not recommended.
- Liver - Use with caution in patients with severe hepatic impairment; dose reduction may be necessary.
- Kidney - No dose adjustment is generally required for patients with mild to moderate renal impairment. Caution is advised in severe impairment.
- Lung - No specific precautions or dose adjustments are generally needed for patients with pre-existing lung conditions.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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