Linamac 10mg Capsule

About

Linagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor, a class of medications widely used in the comprehensive management of type 2 diabetes mellitus. Its primary mechanism of action involves increasing the circulating levels of incretin hormones, specifically glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones are naturally released by the intestine throughout the day and in response to food intake. By inhibiting DPP-4, which normally degrades incretins, linagliptin enhances their activity, leading to glucose-dependent insulin secretion from pancreatic beta cells and a concomitant decrease in glucagon secretion from pancreatic alpha cells. This dual action effectively improves postprandial and fasting glycemic control. A notable advantage of linagliptin is its primary excretion unchanged via the enterohepatic system, which eliminates the need for dose adjustment in patients with any degree of renal impairment, making it a versatile option for a broad patient population.

Uses

• Type 2 diabetes mellitus (monotherapy)
• Type 2 diabetes mellitus (combination therapy)
• Improve glycemic control
• Reduce HbA1c levels

Directions For Use

Take one capsule orally once daily, with or without food, as prescribed by your doctor.

Benefits

• Effective in lowering blood glucose
• Low risk of hypoglycemia (when used alone)
• Weight-neutral effect
• No dose adjustment needed for renal impairment
• Convenient once-daily dosing
• Well-tolerated

Side Effects

• Nasopharyngitis
• Cough
• Diarrhea
• Headache
• Hypoglycemia (especially with sulfonylureas/insulin)
• Pancreatitis (rare)
• Arthralgia (joint pain)
• Hypersensitivity reactions
• Rash
• Constipation
• Urinary tract infection
• Back pain

Safety Measures

• Alcohol - Moderate alcohol intake is generally acceptable, but excessive consumption may affect blood sugar levels.
• Pregnancy - Not recommended during pregnancy; use only if potential benefit justifies the risk to the fetus.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it passes into breast milk.
• Liver - Use with caution in patients with severe hepatic impairment; monitoring is advised.
• Kidney - No dose adjustment is required for any degree of renal impairment, making it a preferred option.
• Lung - Generally safe for lung conditions; no specific precautions related to pulmonary function.

Disclaimer

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