LORANZA 2MG

About

Lorazepam is a potent benzodiazepine medication that exerts its therapeutic effects by enhancing the activity of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. By binding to specific benzodiazepine receptors on the GABA-A receptor complex, it increases the frequency of chloride channel opening, leading to hyperpolarization of neurons and a reduction in neuronal excitability. This action results in significant anxiolytic, sedative, hypnotic, anticonvulsant, and muscle relaxant properties. The 2mg dosage is commonly used for the short-term management of acute anxiety disorders, insomnia, and as an adjunct in the treatment of status epilepticus or alcohol withdrawal syndrome. Its relatively rapid onset and intermediate duration of action make it effective for acute symptom control. However, due to the risk of tolerance, dependence, and withdrawal symptoms, particularly with prolonged use, it is generally recommended for short-term therapy. Careful clinical assessment and patient monitoring are essential to ensure safe and effective use.

Uses

• Short-term management of anxiety disorders
• Treatment of insomnia
• Control of status epilepticus (severe seizures)
• Pre-anesthetic medication for sedation

Directions For Use

Take one tablet orally exactly as prescribed by your doctor, usually for short periods due to potential for dependence.

Benefits

• Rapid relief of acute anxiety symptoms
• Effective for promoting sleep
• Helps control seizures
• Reduces agitation and restlessness
• Provides muscle relaxant properties
• Useful for pre-operative sedation

Side Effects

• Drowsiness or sedation
• Dizziness or lightheadedness
• Confusion or disorientation
• Impaired coordination (ataxia)
• Memory impairment (amnesia)
• Fatigue
• Headache
• Blurred vision
• Nausea or dry mouth
• Paradoxical excitement or aggression
• Respiratory depression
• Dependence and withdrawal symptoms

Safety Measures

• Alcohol - Significantly increases CNS depressant effects, leading to severe drowsiness, respiratory depression, and impaired coordination. Avoid completely.
• Pregnancy - May cause harm to the fetus, including congenital malformations and neonatal withdrawal syndrome. Generally not recommended; consult your doctor.
• Breastfeeding - Passes into breast milk and can cause sedation, poor feeding, and weight loss in the infant. Not recommended; consult your physician.
• Liver - Use with extreme caution in patients with hepatic impairment, as metabolism is significantly affected. Dose adjustment or avoidance is often necessary.
• Kidney - Use with caution in patients with renal impairment, as excretion may be affected. Dose adjustment may be necessary, especially in severe impairment.
• Lung - Use with extreme caution in patients with severe respiratory insufficiency (e.g., COPD, sleep apnea) as it can significantly worsen respiratory depression.

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