Mapsgem 1gm Injection

About

Gemcitabine is a pyrimidine antimetabolite that functions as a nucleoside analog, primarily used in chemotherapy for various solid tumors. It exerts its cytotoxic effects by inhibiting DNA synthesis and repair, leading to cell cycle arrest and apoptosis. Once inside the cell, gemcitabine is phosphorylated to its active diphosphate and triphosphate forms. Gemcitabine diphosphate inhibits ribonucleotide reductase, reducing the deoxyribonucleotide pool necessary for DNA synthesis, while gemcitabine triphosphate is incorporated into DNA, causing chain termination and inhibiting DNA polymerase. This dual mechanism makes it a potent agent against rapidly dividing cancer cells. It is administered intravenously and is often a cornerstone in combination regimens for advanced malignancies. Its efficacy is well-established in improving progression-free and overall survival in specific cancer types, making it a crucial component of modern oncology protocols.

Uses

• Pancreatic cancer
• Non-small cell lung cancer
• Breast cancer
• Ovarian cancer

Directions For Use

Administered intravenously by a healthcare professional. Dosage and frequency depend on the specific cancer and patient's condition.

Benefits

• Effective against several solid tumors
• Can improve survival rates
• Often used in combination therapies
• Relatively well-tolerated compared to some other chemotherapies
• Available in different strengths
• Can reduce tumor burden

Side Effects

• Myelosuppression (anemia, leukopenia, thrombocytopenia)
• Nausea
• Vomiting
• Fatigue
• Fever
• Rash
• Hair loss
• Flu-like symptoms
• Elevated liver enzymes
• Proteinuria
• Dyspnea
• Peripheral edema

Safety Measures

• Alcohol - Avoid alcohol due to potential for increased liver toxicity and gastrointestinal irritation.
• Pregnancy - Contraindicated in pregnancy as it can cause fetal harm. Effective contraception is required.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant.
• Liver - Use with caution in patients with pre-existing liver impairment; dose adjustments may be necessary.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary.
• Lung - Monitor for pulmonary toxicity, including interstitial pneumonitis and acute respiratory distress syndrome.

Disclaimer

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