Megaplat 100mg Injection

About

Megaplat Injection, containing oxaliplatin, is a platinum-based antineoplastic agent primarily used in the treatment of various cancers. Its mechanism of action involves forming inter- and intra-strand DNA cross-links, which inhibits DNA replication and transcription, ultimately leading to programmed cell death in rapidly dividing cancer cells. This cytotoxic effect makes it a crucial component in many chemotherapy regimens, particularly for advanced or metastatic disease. It is often administered in combination with other chemotherapeutic agents to enhance efficacy and overcome potential drug resistance.

The drug's unique chemical structure, featuring a diaminocyclohexane (DACH) carrier ligand, contributes to its distinct activity profile and helps to overcome some resistance mechanisms seen with other platinum compounds. Megaplat is typically given intravenously under the supervision of an oncologist, with dosage and treatment duration tailored to the specific cancer type, stage, and patient's overall health and renal function. Regular monitoring of blood counts and neurological function is essential during treatment.

Uses

• Treatment of advanced colorectal cancer.
• Adjuvant treatment of stage III colon cancer.
• Management of gastric cancer.
• Treatment of pancreatic cancer.

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion rate are determined by the physician based on the patient's condition.

Benefits

• Effective against a range of solid tumors.
• Crucial component in combination chemotherapy.
• Improves progression-free and overall survival.
• Well-established and widely used in oncology.
• Targets rapidly dividing cancer cells effectively.
• Manageable side effect profile with supportive care.

Side Effects

• Peripheral neuropathy (sensory and motor)
• Nausea and vomiting
• Fatigue and asthenia
• Diarrhea or constipation
• Myelosuppression (anemia, leukopenia, thrombocytopenia)
• Stomatitis/mucositis
• Alopecia (hair thinning or loss)
• Allergic reactions (rash, pruritus, bronchospasm)
• Elevated liver enzymes
• Renal dysfunction
• Abdominal pain
• Headache

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects and potentially increase liver strain.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm. Women of childbearing potential must use effective contraception during and for a period after treatment.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and pose risks to the infant.
• Liver - Use with caution in patients with hepatic impairment. Dose adjustments may be necessary, and liver function should be closely monitored.
• Kidney - Use with caution in patients with renal impairment. Dose adjustments are often required based on creatinine clearance, and kidney function should be regularly assessed.
• Lung - Rare but serious pulmonary toxicity, including interstitial lung disease, can occur. Monitor for new or worsening respiratory symptoms.

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