Megarest 160mg Tablet

About

Megarest 160mg Tablet contains megestrol acetate, a synthetic progestin with both antineoplastic and appetite-stimulating properties. In oncology, it is used in the palliative treatment of advanced breast and endometrial cancers, where its hormonal effects can modulate tumor growth. Its primary mechanism in cancer involves anti-estrogenic effects and direct cytotoxic actions on hormone-sensitive cells.

Beyond its antineoplastic role, megestrol acetate is widely recognized for its ability to stimulate appetite and promote weight gain in patients experiencing cachexia or significant weight loss due1 to AIDS, cancer, or other chronic illnesses. This effect is thought to be mediated through its impact on cytokine production and hypothalamic appetite regulation. Careful monitoring for potential side effects, particularly thromboembolic events, is important.

Uses

• Appetite stimulation and weight gain in cachexia
• Palliative treatment of advanced breast cancer
• Palliative treatment of advanced endometrial cancer
• Management of anorexia in AIDS patients

Directions For Use

Take orally, usually once daily, with or without food, as prescribed by your physician.

Benefits

• Stimulates appetite effectively
• Promotes weight gain in wasting syndromes
• Palliative treatment for certain cancers
• Improves quality of life in cachectic patients
• Convenient oral dosage form
• Can help manage cancer-related anorexia

Side Effects

• Weight gain
• Thromboembolic events (e.g., DVT, pulmonary embolism)
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Breakthrough bleeding/spotting
• Hot flashes
• Fluid retention
• Headache
• Insomnia
• Adrenal suppression (with long-term high doses)

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol may worsen general health or interact with other medications.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm, including feminization of male fetuses.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and potentially affect the infant.
• Liver - Use with caution in patients with liver impairment. Liver function should be monitored, especially with long-term use.
• Kidney - Use with caution in patients with renal impairment. Dosage adjustments may be necessary, and kidney function should be monitored.
• Lung - Use with caution in patients with a history of pulmonary embolism or other thromboembolic disorders due to increased risk.

Disclaimer

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