MEXT 7.5 10S

About

MEXT 7.5 contains Methotrexate, a well-established antimetabolite and immunosuppressant medication. Its primary mechanism of action involves inhibiting dihydrofolate reductase, an enzyme crucial for the synthesis of DNA, RNA, and proteins, which are essential for cell replication. This inhibitory effect predominantly targets rapidly dividing cells, such as immune cells involved in inflammatory processes and certain cancer cells. In the lower doses typically prescribed for autoimmune conditions like rheumatoid arthritis and psoriasis, Methotrexate effectively reduces inflammation and suppresses the overactive immune system. This modulation helps in managing disease activity and slowing disease progression. The 7.5mg dosage is a common weekly regimen for these chronic conditions, carefully balanced to achieve therapeutic immune modulation while minimizing systemic toxicity. Due to its narrow therapeutic index, close patient monitoring is absolutely essential throughout the treatment course.

Uses

• Treatment of severe active rheumatoid arthritis.
• Management of severe, recalcitrant psoriasis.
• Therapy for certain types of cancer (at higher doses).
• Prevention of graft-versus-host disease (off-label).

Directions For Use

Take MEXT 7.5 exactly once a week on the same day each week, as prescribed by your doctor. It is crucial to take folic acid supplementation as directed to reduce side effects.

Benefits

• Effectively reduces inflammation in autoimmune diseases.
• Slows the progression of rheumatoid arthritis.
• Clears psoriatic skin lesions.
• Reduces the need for corticosteroids.
• Long-term disease control for chronic conditions.
• Well-established efficacy in its indications.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Stomatitis (mouth sores)
• Hair loss
• Fatigue
• Headache
• Dizziness
• Elevated liver enzymes
• Bone marrow suppression (leukopenia, thrombocytopenia)
• Pulmonary fibrosis (rare, but serious)
• Increased susceptibility to infections

Safety Measures

• Alcohol - Alcohol consumption should be strictly avoided or severely limited while taking MEXT 7.5, as it significantly increases the risk of liver toxicity.
• Pregnancy - MEXT 7.5 is highly teratogenic and contraindicated in pregnancy. Effective contraception must be used by both male and female patients during and for a period after treatment.
• Breastfeeding - MEXT 7.5 is excreted in breast milk and can cause serious adverse effects in the infant. Breastfeeding is contraindicated during treatment.
• Liver - MEXT 7.5 is hepatotoxic. It is contraindicated in patients with severe liver disease. Liver function tests must be monitored regularly before and during treatment.
• Kidney - MEXT 7.5 is primarily excreted by the kidneys. It is contraindicated in patients with severe renal impairment. Dose adjustments are necessary for moderate impairment, and renal function must be closely monitored.
• Lung - MEXT 7.5 can cause severe, potentially fatal pulmonary toxicity (e.g., pneumonitis, fibrosis). Use with extreme caution in patients with pre-existing lung disease, and monitor for respiratory symptoms.

Disclaimer

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