Myaza 100mg Injection

About

Myaza 100mg Injection contains Azacitidine, a potent pyrimidine nucleoside analog that functions as a hypomethylating agent. Its mechanism involves incorporation into DNA and RNA, leading to global DNA hypomethylation. This process reactivates tumor suppressor genes and genes involved in cell differentiation and proliferation that have been aberrantly silenced by hypermethylation in malignant cells. Additionally, Azacitidine exerts direct cytotoxicity on abnormal hematopoietic cells in the bone marrow. This dual action helps to restore normal hematopoiesis and reduce the burden of malignant cells. It is primarily indicated for the treatment of myelodysplastic syndromes (MDS) across all French-American-British (FAB) subtypes, including refractory anemia with excess blasts (RAEB), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML) with 20-30% blasts. Its use aims to improve hematological parameters, reduce transfusion dependence, and prolong survival in these high-risk patient populations.

Uses

• Myelodysplastic Syndromes (MDS)
• Chronic Myelomonocytic Leukemia (CMML)
• Acute Myeloid Leukemia (AML) with 20-30% blasts
• Refractory anemia with excess blasts (RAEB)

Directions For Use

Administered subcutaneously or intravenously by a healthcare professional. Dosage and schedule are determined by the physician.

Benefits

• Improves hematological parameters in MDS.
• Delays progression to AML.
• Extends overall survival in high-risk MDS.
• Reduces transfusion dependence.
• Targets aberrant DNA methylation.
• Approved for various MDS subtypes.

Side Effects

• Nausea and vomiting
• Diarrhea
• Constipation
• Fatigue
• Injection site reactions (erythema, pain)
• Fever
• Neutropenia
• Thrombocytopenia
• Anemia
• Pneumonia
• Hypokalemia
• Elevated liver enzymes

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm; use effective contraception during treatment.
• Breastfeeding - Advise against breastfeeding due to the potential for serious adverse reactions in breastfed infants.
• Liver - Use with caution in patients with severe hepatic impairment; monitor liver function closely.
• Kidney - Use with caution in patients with renal impairment; dose adjustment may be necessary.
• Lung - Monitor for new or worsening pulmonary symptoms, including interstitial lung disease.

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