Neolimid 10mg Capsule

About

Lenalidomide is an immunomodulatory drug (IMiD) with a multifaceted mechanism of action, encompassing anti-neoplastic, anti-angiogenic, and immunomodulatory properties. It is a cornerstone in the treatment of multiple myeloma, myelodysplastic syndromes (MDS) with a specific deletion on chromosome 5q, and mantle cell lymphoma. Lenalidomide directly inhibits tumor cell proliferation, induces apoptosis, and modulates the immune system by enhancing T-cell and NK-cell activity while suppressing regulatory T-cells. Additionally, it inhibits angiogenesis, thereby starving tumors of their blood supply. Its complex interplay of effects makes it a powerful therapeutic agent, significantly improving response rates and survival in patients with these challenging hematological conditions.

Uses

• Multiple myeloma
• Myelodysplastic syndromes (MDS) with del(5q)
• Mantle cell lymphoma
• Follicular lymphoma (in combination)

Directions For Use

Take orally once daily with water, with or without food, at approximately the same time each day.

Benefits

• Immunomodulatory and anti-neoplastic
• Effective in multiple myeloma
• Treats specific MDS subtype
• Oral administration
• Improves response rates and survival
• Used in combination therapies

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia)
• Fatigue
• Diarrhea
• Constipation
• Rash
• Peripheral neuropathy
• Deep vein thrombosis (DVT)
• Pulmonary embolism (PE)
• Muscle cramps
• Nausea
• Fever
• Tumor flare reaction

Safety Measures

• Alcohol - No specific interaction with alcohol, but general health advice applies.
• Pregnancy - Contraindicated during pregnancy due to severe teratogenicity; strict risk management program required.
• Breastfeeding - Avoid breastfeeding due to potential for serious adverse reactions in the infant.
• Liver - Use with caution in hepatic impairment; monitor liver function closely.
• Kidney - Dose adjustment is required in patients with renal impairment.
• Lung - Monitor for pulmonary hypertension and interstitial lung disease, though rare.

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