Nzalut 40mg Capsule

About

Nzalut (enzalutamide) is an androgen receptor inhibitor used in the treatment of prostate cancer. It works by blocking multiple steps in the androgen receptor signaling pathway, which is crucial for the growth and survival of prostate cancer cells. Enzalutamide exerts its anti-tumor effects by inhibiting androgen binding to the androgen receptor, preventing the nuclear translocation of the activated receptor, and impairing its binding to DNA. This comprehensive blockade effectively reduces the proliferation of cancer cells and induces apoptosis. It is particularly indicated for metastatic castration-resistant prostate cancer (mCRPC), non-metastatic castration-resistant prostate cancer (nmCRPC), and metastatic hormone-sensitive prostate cancer (mHSPC), where it helps to prolong survival, delay disease progression, and improve clinical outcomes for men whose cancer has progressed despite conventional hormone therapy.

Uses

• Metastatic castration-resistant prostate cancer (mCRPC)
• Non-metastatic castration-resistant prostate cancer (nmCRPC)
• Metastatic hormone-sensitive prostate cancer (mHSPC)
• Used in men who have failed prior androgen deprivation therapy

Directions For Use

Take orally, usually once daily, with or without food. Swallow capsules/tablets whole.

Benefits

• Prolongs survival in mCRPC patients
• Delays disease progression
• Reduces risk of skeletal-related events
• Oral administration for convenience
• Effective even after chemotherapy failure
• Improves quality of life for many patients

Side Effects

• Fatigue
• Hot flashes
• Hypertension (high blood pressure)
• Headache
• Diarrhea
• Nausea
• Decreased appetite
• Peripheral edema
• Falls
• Seizures (rare but serious)
• Fractures
• Cardiovascular events

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it may exacerbate fatigue and potentially increase the risk of seizures, though direct interactions are not well-established.
• Pregnancy - Not for use in women. Men should use effective contraception if their partner is pregnant or could become pregnant, as the drug can be present in semen.
• Breastfeeding - Not for use in women. No data available regarding excretion in breast milk.
• Liver - Use with caution in patients with severe liver impairment; dose adjustments may be necessary due to altered drug metabolism.
• Kidney - Use with caution in patients with severe kidney impairment; dose adjustments may be necessary as the drug and its metabolites are excreted renally.
• Lung - No specific lung-related safety concerns, but monitor for any new or worsening respiratory symptoms as part of general patient care.

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