Oncolet 2.5mg Tablet

About

Oncolet 2.5mg Tablet, containing letrozole, is a potent and highly selective non-steroidal aromatase inhibitor. It is primarily used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women. Aromatase is an enzyme responsible for converting androgens into estrogens in peripheral tissues, which is the main source of estrogen in postmenopausal women. By inhibiting aromatase, letrozole significantly reduces circulating estrogen levels, thereby depriving estrogen-dependent breast cancer cells of the growth stimulus they require.

This mechanism makes Oncolet an effective therapy for both early-stage and advanced breast cancer. It is often prescribed as adjuvant therapy following surgery, as extended adjuvant therapy after tamoxifen, or as first-line treatment for metastatic disease. Its oral administration offers convenience, but consistent adherence is crucial for optimal therapeutic outcomes. Regular monitoring for bone mineral density and lipid profiles is recommended due to potential side effects.

Uses

• Adjuvant treatment of early hormone-receptor-positive breast cancer.
• Extended adjuvant treatment of early breast cancer.
• First-line treatment of advanced breast cancer.
• Neoadjuvant treatment in certain cases.

Directions For Use

Take Oncolet 2.5mg Tablet orally once daily, with or without food. It is important to take it at approximately the same time each day.

Benefits

• Highly effective in hormone-receptor-positive breast cancer.
• Significantly reduces breast cancer recurrence risk.
• Improves disease-free and overall survival.
• Convenient oral once-daily administration.
• Well-tolerated by many patients.
• Established as a standard of care.

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Fatigue and lethargy
• Nausea
• Headache
• Dizziness
• Bone thinning (osteoporosis)
• Increased cholesterol levels
• Sweating
• Weight gain
• Hair thinning
• Vaginal dryness

Safety Measures

• Alcohol - No direct interaction with alcohol. However, excessive alcohol consumption can increase the risk of certain cancers, so moderation is advised.
• Pregnancy - Oncolet is contraindicated during pregnancy as it can cause fetal harm. Women of childbearing potential should use effective contraception if there is any possibility of pregnancy.
• Breastfeeding - Breastfeeding is not recommended during Oncolet treatment, as the drug may pass into breast milk and could potentially harm the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary in severe cases, and liver function should be monitored.
• Kidney - Use with caution in patients with kidney conditions. No specific dose adjustment is usually needed for mild to moderate impairment, but monitor renal function.
• Lung - No specific lung-related safety concerns are directly associated with Oncolet.

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