ONGLYZA 2.5MG 1

About

Saxagliptin is an oral antidiabetic agent belonging to the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It works by inhibiting the enzyme DPP-4, which is responsible for the rapid degradation of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By preventing the breakdown of these incretins, saxagliptin increases their levels, leading to enhanced glucose-dependent insulin secretion from pancreatic beta cells and reduced glucagon secretion from pancreatic alpha cells. This dual action helps to lower blood glucose levels in patients with type 2 diabetes mellitus, particularly after meals.

It is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. Saxagliptin offers the benefit of improving blood sugar control with a low risk of hypoglycemia when used as monotherapy or in combination with medications that do not typically cause hypoglycemia. It is a valuable option for patients seeking to manage their blood glucose effectively.

Uses

• Improvement of glycemic control in adults with type 2 diabetes mellitus.
• Used as monotherapy when metformin is inappropriate.
• Used in combination with metformin, sulfonylureas, or thiazolidinediones.
• Adjunct to diet and exercise for blood sugar management.

Directions For Use

Take once daily, with or without food, as directed by your healthcare provider.

Benefits

• Effectively lowers blood sugar levels.
• Improves glycemic control in type 2 diabetes.
• Generally well-tolerated with a low risk of hypoglycemia when used alone.
• Can be used in combination with other antidiabetic agents.
• Convenient once-daily dosing.
• Helps to maintain stable blood glucose throughout the day.

Side Effects

• Upper respiratory tract infection
• Urinary tract infection
• Headache
• Nasopharyngitis
• Sinusitis
• Abdominal pain
• Diarrhea
• Nausea
• Peripheral edema
• Hypoglycemia (especially with sulfonylurea)
• Joint pain (arthralgia)
• Pancreatitis (rare but serious)

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake can affect blood sugar levels. Monitor blood glucose closely.
• Pregnancy - Saxagliptin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
• Breastfeeding - It is not known whether saxagliptin is excreted in human milk. A decision should be made whether to discontinue nursing or the drug.
• Liver - No dose adjustment is typically required for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment.
• Kidney - Dose adjustment is required for patients with moderate to severe renal impairment and end-stage renal disease.
• Lung - Postmarketing reports of bullous pemphigoid have occurred with DPP-4 inhibitors. Monitor for skin lesions.

Disclaimer

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