Oreta 2.5mg Tablet

About

Letrozole is a potent and highly selective non-steroidal aromatase inhibitor, primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Its mechanism of action involves competitively binding to the heme of the cytochrome P450 aromatase enzyme, which is responsible for the conversion of androgens into estrogens in peripheral tissues and within the tumor itself. By effectively inhibiting this enzyme, letrozole significantly reduces circulating estrogen levels. This reduction is critical because estrogen can stimulate the growth of hormone-sensitive breast cancer cells. Consequently, letrozole helps to slow or stop the progression of estrogen-dependent tumors, improving disease-free survival and overall outcomes for patients. It is often prescribed as adjuvant therapy after initial treatment or for advanced disease, offering a crucial therapeutic option by depriving cancer cells of estrogen needed for growth.

Uses

• Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women.
• Extended adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women who have completed 5 years of tamoxifen therapy.
• First-line treatment of hormone receptor-positive advanced breast cancer in postmenopausal women.
• Treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.

Directions For Use

Take one tablet orally once daily, with or without food, at approximately the same time each day. Follow your doctor's instructions precisely.

Benefits

• Significantly reduces estrogen levels in postmenopausal women.
• Effective in treating hormone receptor-positive breast cancer.
• Can improve disease-free survival and overall survival.
• Offers an alternative to tamoxifen in certain settings.
• Helps prevent recurrence of breast cancer.
• Available as an oral tablet for convenient administration.

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Fatigue
• Nausea
• Headache
• Bone pain/osteoporosis
• Hair thinning
• Dizziness
• Weight gain
• Edema
• Cholesterol elevation
• Vaginal dryness

Safety Measures

• Alcohol - Moderate alcohol consumption is generally considered safe, but excessive intake may exacerbate hot flashes or other side effects. Discuss with your doctor.
• Pregnancy - Letrozole is contraindicated in premenopausal women and during pregnancy due to its potential to cause fetal harm. Effective contraception is essential for women of childbearing potential.
• Breastfeeding - Breastfeeding is contraindicated during letrozole treatment as it is unknown if the drug is excreted in human milk and could harm the infant.
• Liver - Use with caution in patients with severe liver impairment. Dose reduction may be necessary, and liver function should be monitored due to potential for increased drug exposure.
• Kidney - No dose adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment, though data is limited.
• Lung - No specific contraindications or significant precautions related to lung conditions are typically associated with letrozole.

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