Pabreca 100mg Capsule

About

Pabreca 100mg Capsule is an antineoplastic agent belonging to the class of poly (ADP-ribose) polymerase (PARP) inhibitors. It works by blocking the PARP enzyme, which is critically involved in DNA repair pathways within cells. By inhibiting PARP, Pabreca prevents cancer cells from effectively repairing their damaged DNA, leading to an accumulation of genetic damage and ultimately inducing cell death. This mechanism is particularly effective in cancer cells that already possess existing DNA repair defects, such as those with BRCA gene mutations, a concept known as synthetic lethality. Pabreca is typically utilized in the treatment of specific types of cancer, often in maintenance settings following initial chemotherapy or in patients with advanced disease.

Its targeted action helps to selectively eliminate cancer cells while minimizing harm to healthy cells, though systemic side effects can still occur. The oral administration offers convenience for long-term treatment regimens.

Uses

• Ovarian cancer (maintenance therapy)
• Breast cancer (HER2-negative, BRCA-mutated)
• Pancreatic cancer (BRCA-mutated)
• Prostate cancer (metastatic castration-resistant, BRCA-mutated)

Directions For Use

Take orally as directed by your physician, usually twice daily, with or without food. Swallow the capsule whole.

Benefits

• Targets specific DNA repair pathways in cancer cells.
• Effective in BRCA-mutated cancers.
• May extend progression-free survival.
• Oral administration offers convenience.
• Can be used as maintenance therapy.
• Reduces tumor growth and spread.

Side Effects

• Nausea
• Vomiting
• Fatigue
• Anemia
• Diarrhea
• Abdominal pain
• Decreased appetite
• Myelosuppression (low blood counts)
• Headache
• Dysgeusia (taste disturbance)
• Rash
• Stomatitis

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or liver toxicity associated with this medication.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm. Effective contraception is required during treatment and for a period after.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and potentially harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary based on liver function.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary based on creatinine clearance.
• Lung - Rarely, pneumonitis can occur; monitor for new or worsening respiratory symptoms such as cough or shortness of breath.

Disclaimer

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