Paclibenz 260mg Injection

About

Paclitaxel is a potent antineoplastic agent classified within the taxane family, extensively utilized in the treatment of a diverse range of solid tumors. Its primary mechanism of action involves the disruption of microtubule dynamics, which are critical for cellular processes, particularly cell division. Paclitaxel binds to and stabilizes microtubules, preventing their normal depolymerization. This stabilization leads to the accumulation of non-functional microtubules, thereby arresting the cell cycle in the G2/M phase. Consequently, this disruption triggers programmed cell death, or apoptosis, in rapidly proliferating cancer cells. This unique cytotoxic mechanism underpins its efficacy against various malignancies, making it a cornerstone in many chemotherapy regimens. It is typically administered intravenously, often requiring premedication to mitigate potential hypersensitivity reactions, and its therapeutic index necessitates careful monitoring of patient parameters throughout the course of treatment.

Uses

• Treatment of ovarian cancer.
• Adjuvant and metastatic breast cancer.
• Non-small cell lung cancer.
• AIDS-related Kaposi's sarcoma.

Directions For Use

Administered intravenously by a healthcare professional. Dosage and infusion rate are determined by the patient's condition and specific cancer type.

Benefits

• Effective against various solid tumors.
• Induces apoptosis in cancer cells.
• Can be used as a first-line or subsequent therapy.
• Improves progression-free survival in certain cancers.
• Part of established chemotherapy regimens.
• Available in different formulations for patient needs.

Side Effects

• Myelosuppression (low blood counts)
• Peripheral neuropathy
• Alopecia (hair loss)
• Hypersensitivity reactions
• Arthralgia (joint pain)
• Myalgia (muscle pain)
• Nausea and vomiting
• Diarrhea
• Mucositis (inflammation of mucous membranes)
• Fatigue
• Bradycardia (slow heart rate)
• Hypotension (low blood pressure)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate side effects like nausea or liver strain.
• Pregnancy - Paclitaxel is contraindicated in pregnancy due to potential fetal harm. Effective contraception is required for patients of reproductive potential.
• Breastfeeding - Breastfeeding is not recommended during paclitaxel treatment and for a period after, as the drug may be excreted in breast milk and harm the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary due to altered drug metabolism and increased toxicity risk.
• Kidney - Use with caution in patients with severe kidney impairment; monitoring for toxicity is crucial, though renal excretion is not the primary elimination route.
• Lung - Rare but serious pulmonary toxicity, including interstitial pneumonia, has been reported. Monitor for new or worsening respiratory symptoms.

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