Palonoget 0.25mg Injection

About

Palonoget 0.25mg Injection contains palonosetron, a highly selective 5-HT3 receptor antagonist. This medication works by blocking the action of serotonin, a natural substance in the body that can trigger nausea and vomiting, particularly in response to chemotherapy or surgery. By binding to and inhibiting 5-HT3 receptors located in the gastrointestinal tract and the central nervous system, Palonoget effectively prevents both acute and delayed phases of chemotherapy-induced nausea and vomiting (CINV), as well as postoperative nausea and vomiting (PONV). Its prolonged duration of action and high receptor binding affinity distinguish it from other antiemetics, providing extended protection and significantly improving patient comfort and quality of life during and after medical procedures that typically induce emesis.

Uses

• Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV).
• Prevention of postoperative nausea and vomiting (PONV).
• Used in patients receiving moderately or highly emetogenic chemotherapy.
• To improve patient comfort and reduce complications associated with nausea and vomiting.

Directions For Use

This medication is administered as an intravenous injection by a healthcare professional. It is typically given before chemotherapy or surgery as directed by your doctor.

Benefits

• Highly effective in preventing both acute and delayed CINV.
• Provides prolonged antiemetic protection due to its long half-life.
• Reduces the incidence and severity of postoperative nausea and vomiting.
• Improves patient quality of life during chemotherapy treatment.
• Helps patients adhere to their chemotherapy regimens.
• Offers a convenient single-dose administration for extended effect.

Side Effects

• Headache
• Constipation
• Diarrhea
• Dizziness
• Fatigue
• Bradycardia (slow heart rate)
• Hypotension (low blood pressure)
• Injection site reactions (pain, redness)
• Abdominal pain
• Insomnia
• Anxiety
• QT prolongation (rare, dose-dependent)

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol may worsen nausea or dizziness.
• Pregnancy - Use only if clearly needed; consult your doctor. Animal studies show no harm, but human data is limited.
• Breastfeeding - It is unknown if it passes into breast milk. Consult your doctor before breastfeeding.
• Liver - No dose adjustment is generally needed for liver impairment. Use with caution in severe cases.
• Kidney - No dose adjustment is generally needed for kidney impairment. Use with caution in severe cases.
• Lung - No specific lung-related safety concerns.

Disclaimer

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