Palside 125mg Tablet

About

Palside 125mg Tablet contains a potent and selective cyclin-dependent kinase (CDK) 4 and 6 inhibitor, a crucial class of targeted therapy in modern oncology. This medication functions by specifically blocking the activity of CDK4 and CDK6, which are key enzymes that regulate the progression of cells through the cell cycle. In many cancers, these kinases are overactive, leading to uncontrolled cell division. By inhibiting these specific targets, Palside effectively prevents cancer cells from advancing from the G1 phase to the S phase of the cell cycle, thereby halting their proliferation and growth. It is primarily indicated for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. This targeted approach, often used in combination with endocrine therapy, offers a significant advantage by specifically disrupting cancer cell growth pathways while minimizing impact on healthy cells, ultimately aiming to slow tumor progression and improve patient outcomes.

Uses

• Treatment of HR-positive, HER2-negative advanced or metastatic breast cancer.
• Used in combination with an aromatase inhibitor as initial endocrine-based therapy.
• Used in combination with fulvestrant in women with disease progression following endocrine therapy.
• To inhibit the growth and spread of specific types of breast cancer cells.

Directions For Use

Take this tablet orally as directed by your doctor, usually once daily for 21 consecutive days, followed by 7 days off. Swallow the tablet whole with food to ensure proper absorption.

Benefits

• Significantly prolongs progression-free survival in eligible patients.
• Offers a targeted therapy approach for specific breast cancer types.
• Can be used effectively in combination with existing endocrine therapies.
• Helps to slow down the growth and spread of cancer cells.
• Provides a valuable treatment option for advanced or metastatic breast cancer.
• Improves clinical outcomes for HR-positive, HER2-negative patients.

Side Effects

• Neutropenia (low white blood cell count)
• Leukopenia (low total white blood cell count)
• Fatigue
• Nausea
• Diarrhea
• Stomatitis (mouth sores)
• Hair thinning or loss (alopecia)
• Anemia (low red blood cell count)
• Thrombocytopenia (low platelet count)
• Infections
• Vomiting
• Rash

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may worsen certain side effects or interact with the medication.
• Pregnancy - Not recommended during pregnancy due to potential harm to the fetus. Effective contraception is advised for women of childbearing potential.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after the last dose due to potential harm to the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary. Regular liver function monitoring is advised.
• Kidney - Use with caution in patients with kidney impairment; dose adjustments may be necessary. Regular kidney function monitoring is advised.
• Lung - Rarely, interstitial lung disease/pneumonitis can occur. Report any new or worsening respiratory symptoms immediately.

Disclaimer

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