Pempro 100mg Injection

About

Pempro 100mg Injection contains pemetrexed, an antifolate antineoplastic agent that exerts its cytotoxic effects by disrupting folate-dependent metabolic processes essential for cell replication. It inhibits several key enzymes involved in purine and pyrimidine synthesis, including thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). This multi-targeted inhibition leads to the depletion of nucleotide precursors, thereby inhibiting DNA and RNA synthesis and ultimately inducing cell death in rapidly dividing cancer cells. Pemetrexed is commonly used in the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma. To mitigate severe toxicities, patients are typically pre-medicated with folic acid and vitamin B12 supplements, and corticosteroids are often administered to reduce skin reactions.

Uses

• Treatment of malignant pleural mesothelioma.
• First-line treatment of non-small cell lung cancer (NSCLC).
• Maintenance treatment of non-small cell lung cancer (NSCLC).
• Second-line treatment of non-small cell lung cancer (NSCLC).

Directions For Use

Administered intravenously by a healthcare professional. Pre-medication with folic acid, vitamin B12, and corticosteroids is required.

Benefits

• Effective against specific types of lung cancer and mesothelioma.
• Can be used as first-line, maintenance, or second-line therapy.
• Improves progression-free survival in eligible patients.
• Offers a targeted approach to inhibit cancer cell growth.
• Part of established chemotherapy regimens.
• May improve overall survival in certain patient populations.

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Fatigue
• Nausea and vomiting
• Diarrhea
• Constipation
• Stomatitis/Mucositis
• Rash
• Fever
• Anorexia
• Peripheral neuropathy
• Renal dysfunction
• Infections

Safety Measures

• Alcohol - Alcohol should be avoided during treatment as it may exacerbate liver toxicity and other side effects.
• Pregnancy - Pemetrexed is teratogenic and embryotoxic. It is contraindicated in pregnancy. Effective contraception is required.
• Breastfeeding - Breastfeeding is contraindicated during treatment due to the potential for serious adverse reactions in the infant.
• Liver - Use with caution in patients with mild to moderate hepatic impairment; severe impairment requires careful consideration.
• Kidney - Dose adjustment is necessary for patients with moderate to severe renal impairment. Not recommended for severe impairment.
• Lung - Used to treat lung cancer; however, monitor for interstitial lung disease as a rare but serious side effect.

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