PRICHEK GMP 2 10

About

PRICHEK GMP 2 is a combination medication used in the management of type 2 diabetes mellitus. It contains Glimepiride, a sulfonylurea, and Metformin, a biguanide. Glimepiride works by stimulating the beta cells in the pancreas to release more insulin, thereby helping to lower blood glucose levels. Metformin, on the other hand, primarily reduces glucose production in the liver and improves the body's sensitivity to insulin, allowing cells to absorb more glucose from the blood. It also decreases glucose absorption from the gastrointestinal tract.

This dual-action approach provides comprehensive glycemic control, addressing both insulin secretion and insulin resistance, which are key pathophysiological defects in type 2 diabetes. PRICHEK GMP 2 is typically prescribed when diet, exercise, and monotherapy with either Glimepiride or Metformin alone are insufficient to achieve adequate blood sugar control. It helps to reduce fasting and post-meal glucose levels, contributing to better long-term diabetes management and reducing the risk of associated complications.

Uses

• Management of type 2 diabetes mellitus.
• To improve glycemic control in adults.
• Used as an adjunct to diet and exercise.
• When monotherapy with a single agent is inadequate.

Directions For Use

Take this medicine orally with food, as directed by your physician. Swallow the tablet whole with a glass of water.

Benefits

• Effective blood sugar control.
• Reduces risk of diabetes complications.
• Improves insulin sensitivity.
• Helps in weight management (Metformin component).
• Convenient combination therapy.
• Sustained glycemic improvement.

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Metallic taste
• Lactic acidosis (rare but serious)
• Vitamin B12 deficiency
• Skin rash
• Weight gain (Glimepiride component)
• Upper respiratory tract infection

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis, especially with Metformin.
• Pregnancy - Generally not recommended during pregnancy. Consult your doctor, as insulin therapy is often preferred for gestational diabetes.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and affect the infant. Seek medical advice.
• Liver - Use with caution in patients with liver impairment, as it may increase the risk of lactic acidosis and affect drug metabolism.
• Kidney - Contraindicated in severe kidney impairment due to increased risk of lactic acidosis (Metformin) and accumulation of Glimepiride. Dose adjustment may be needed for moderate impairment.
• Lung - Generally safe for use in patients with stable lung conditions. However, severe respiratory conditions leading to hypoxia can increase lactic acidosis risk.

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