Suregraft 0.25mg Tablet

About

Tacrolimus is a potent immunosuppressant belonging to the calcineurin inhibitor class, primarily used to prevent organ rejection in transplant recipients. Its mechanism involves binding to an intracellular protein, FKBP-12, which then forms a complex that inhibits calcineurin. This inhibition is crucial because calcineurin is responsible for dephosphorylating the nuclear factor of activated T-cells (NFAT), a transcription factor vital for the expression of genes encoding various cytokines, such as interleukin-2. By preventing NFAT activation, tacrolimus effectively blocks the transcription of these cytokines, thereby suppressing T-lymphocyte activation, proliferation, and differentiation. This targeted action significantly dampens the immune response, preventing the body from recognizing and attacking the transplanted organ, thus ensuring graft survival and function.

Uses

• Prophylaxis of organ rejection in kidney transplant recipients.
• Prophylaxis of organ rejection in liver transplant recipients.
• Prophylaxis of organ rejection in heart transplant recipients.
• Treatment of acute rejection episodes resistant to other immunosuppressive regimens.

Directions For Use

Take orally, usually twice daily, on an empty stomach for consistent absorption, or as directed by your transplant physician.

Benefits

• Highly effective in preventing organ transplant rejection.
• Reduces the risk of acute and chronic rejection episodes.
• Allows for successful long-term graft survival.
• Available in various formulations for flexible dosing.
• Can be used in combination with other immunosuppressants.
• Crucial for maintaining the health and function of transplanted organs.

Side Effects

• Nephrotoxicity (kidney damage)
• Neurotoxicity (tremor, headache, seizures)
• Hyperglycemia (high blood sugar)
• Hypertension (high blood pressure)
• Hyperkalemia (high potassium levels)
• Gastrointestinal disturbances (nausea, diarrhea)
• Infections (due to immunosuppression)
• Lymphoproliferative disorders
• Alopecia (hair loss)
• Insomnia
• Anemia
• Peripheral edema

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of liver toxicity or exacerbate side effects, especially neurotoxicity.
• Pregnancy - Tacrolimus can cause fetal harm; use only if the potential benefit justifies the potential risk to the fetus, with careful monitoring and dose adjustment.
• Breastfeeding - Tacrolimus is excreted in breast milk and can cause serious adverse effects in infants; breastfeeding is generally not recommended during treatment.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments are often necessary, and liver function should be closely monitored due to altered metabolism.
• Kidney - Tacrolimus is nephrotoxic; close monitoring of kidney function and tacrolimus trough levels is essential, and dose adjustments may be required to prevent damage.
• Lung - Monitor for signs of pulmonary toxicity, though rare, such as interstitial lung disease, especially in patients with pre-existing lung conditions or risk factors.

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