TACROGRAF 2MG TAB 10 S

About

TACROGRAF Tablets contain Tacrolimus, a potent immunosuppressant medication belonging to the calcineurin inhibitor class. It is primarily used to prevent organ rejection in patients who have undergone solid organ transplantation, such as kidney, liver, or heart transplants. Tacrolimus works by inhibiting the activity of calcineurin, an enzyme crucial for the activation of T-lymphocytes, which are key components of the immune system responsible for recognizing and attacking foreign tissues.

By suppressing the immune response, Tacrolimus helps the body accept the transplanted organ, significantly reducing the risk of rejection. Due to its narrow therapeutic index, careful monitoring of blood levels is essential to ensure efficacy and minimize toxicity. It is often used in combination with other immunosuppressive agents to achieve optimal outcomes and is a cornerstone of post-transplant immunosuppressive regimens.

Uses

• Prevention of organ rejection in kidney transplant recipients
• Prevention of organ rejection in liver transplant recipients
• Prevention of organ rejection in heart transplant recipients
• Treatment of organ rejection in patients unresponsive to other therapies

Directions For Use

Take orally twice daily, preferably on an empty stomach, as directed by your transplant physician. Do not alter dosage without medical advice.

Benefits

• Highly effective in preventing organ rejection
• Improves long-term graft survival
• Reduces the need for re-transplantation
• A cornerstone of post-transplant therapy
• Available in various strengths for precise dosing
• Helps maintain quality of life post-transplant

Side Effects

• Tremor
• Headache
• Nausea
• Diarrhea
• Hypertension (high blood pressure)
• Nephrotoxicity (kidney damage)
• Hyperglycemia (high blood sugar)
• Hyperkalemia (high potassium)
• Infections (increased risk)
• Neurotoxicity (e.g., seizures)
• Alopecia (hair loss)
• Insomnia

Safety Measures

• Alcohol - Avoid alcohol as it can interact with tacrolimus metabolism and increase the risk of side effects, particularly liver toxicity.
• Pregnancy - Tacrolimus can cross the placenta and may cause harm to the fetus. Use only if benefits clearly outweigh risks, with close monitoring.
• Breastfeeding - Tacrolimus is excreted in breast milk. Breastfeeding is generally not recommended due to potential adverse effects on the infant.
• Liver - Use with extreme caution in patients with liver impairment; dosage adjustments are often necessary, and close monitoring of blood levels is crucial.
• Kidney - Tacrolimus is nephrotoxic. Close monitoring of kidney function and tacrolimus blood levels is essential, especially in patients with pre-existing kidney conditions.
• Lung - Use with caution in patients with pre-existing lung conditions, as tacrolimus can rarely cause interstitial lung disease.

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