Myfortic 360mg Tablet

About

Myfortic 360mg Tablet contains Mycophenolic Acid (MPA) in an enteric-coated formulation, which is the active metabolite of mycophenolate mofetil. It is primarily used to prevent organ rejection in adult patients receiving kidney transplants. The enteric coating is designed to reduce gastrointestinal side effects by delaying the release of MPA until it reaches the small intestine, thereby minimizing direct irritation to the stomach. Like mycophenolate mofetil, MPA works by selectively inhibiting inosine monophosphate dehydrogenase, an enzyme critical for the proliferation of B and T lymphocytes, thus suppressing the immune system's response to the transplanted organ.

Myfortic is typically used in combination with other immunosuppressive agents, such as cyclosporine and corticosteroids. It offers an alternative formulation for patients who experience significant gastrointestinal intolerance with mycophenolate mofetil. Lifelong adherence to the prescribed regimen and close monitoring for infections, gastrointestinal issues, and potential malignancies are essential for successful transplant outcomes.

Uses

• Prevention of organ rejection in kidney transplant patients.
• Management of certain autoimmune diseases (off-label).
• Alternative to mycophenolate mofetil for GI intolerance.
• Used in combination with other immunosuppressants.

Directions For Use

Take orally, usually twice daily, on an empty stomach or with food, as directed by your transplant physician. Swallow whole, do not crush or chew.

Benefits

• Effective in preventing kidney transplant rejection.
• Reduced gastrointestinal side effects due to enteric coating.
• Improves patient adherence to immunosuppressive therapy.
• Can be combined with other immunosuppressants.
• Contributes to long-term graft and patient survival.
• Offers a targeted immunosuppressive action.

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Leukopenia (low white blood cell count)
• Anemia
• Thrombocytopenia (low platelet count)
• Increased risk of infections
• Increased risk of certain cancers (lymphoma, skin cancer)
• Headache
• Dizziness
• Hypertension

Safety Measures

• Alcohol - Alcohol can exacerbate gastrointestinal side effects and may increase the risk of liver toxicity. It is generally advisable to avoid or limit alcohol consumption.
• Pregnancy - CONTRAINDICATED. Mycophenolic acid is a known human teratogen, causing severe birth defects. Women of childbearing potential must use two reliable forms of contraception before, during, and for 6 weeks after treatment.
• Breastfeeding - CONTRAINDICATED. Mycophenolic acid is excreted in breast milk and can cause serious adverse effects in a nursing infant. Breastfeeding should be avoided during treatment.
• Liver - Use with caution in patients with severe liver impairment. Dosage adjustments may be necessary, and liver function should be monitored closely.
• Kidney - Use with caution in patients with severe renal impairment. Dosage adjustments may be necessary, and renal function should be monitored closely.
• Lung - Can rarely cause interstitial lung disease or pulmonary fibrosis. Patients should be monitored for new or worsening respiratory symptoms.

Disclaimer

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