Myfortic 180mg Tablet

About

Myfortic (mycophenolic acid, enteric-coated) is an immunosuppressant medication primarily used to prevent organ rejection in patients who have received kidney, heart, or liver transplants. It is the active metabolite of mycophenolate mofetil, directly inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for the de novo synthesis of guanosine nucleotides. This action effectively suppresses the proliferation of T and B lymphocytes, which are key components of the immune system responsible for mediating transplant rejection. The enteric coating helps reduce gastrointestinal side effects often associated with immediate-release formulations, improving patient tolerability and adherence to long-term therapy. Myfortic is a vital component of immunosuppressive regimens, working to maintain the delicate balance required to prevent the body from attacking the new organ while minimizing overall immune suppression.

Uses

• Prevention of kidney transplant rejection
• Prevention of heart transplant rejection
• Prevention of liver transplant rejection
• Treatment of certain autoimmune diseases (off-label)

Directions For Use

Take orally, usually twice daily, on an empty stomach. Do not crush, chew, or break the tablet.

Benefits

• Effectively prevents acute organ rejection episodes
• Improves long-term graft survival rates
• Allows for reduced doses of calcineurin inhibitors
• Targeted immunosuppression of lymphocytes
• Enteric coating reduces GI side effects
• Well-established efficacy in transplant protocols

Side Effects

• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Leukopenia (low white blood cell count)
• Anemia (low red blood cell count)
• Thrombocytopenia (low platelet count)
• Increased risk of infections
• Increased risk of certain cancers (e.g., lymphoma, skin cancer)
• Hypertension
• Headache
• Tremor
• Insomnia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or increase liver strain.
• Pregnancy - Myfortic is highly teratogenic and contraindicated in pregnancy due to severe birth defects. Effective contraception is mandatory.
• Breastfeeding - Not recommended during breastfeeding as mycophenolic acid can pass into breast milk and potentially harm the infant.
• Liver - Use with caution in patients with severe liver impairment; dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Use with caution in patients with severe kidney impairment; dose adjustments may be necessary, and kidney function should be monitored.
• Lung - Monitor for new or worsening respiratory symptoms as interstitial lung disease is a known, though rare, adverse effect.

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