Immutil S 360 Tablet

About

Immutil S 360 Tablet is a crucial immunosuppressant medication primarily utilized in the prophylaxis of organ rejection following allogeneic kidney, heart, or liver transplantation. Its mechanism of action involves the selective, non-competitive, and reversible inhibition of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis pathway of guanosine nucleotides. Lymphocytes, particularly B and T cells, are highly dependent on this pathway for their proliferation, unlike other cell types which can utilize salvage pathways. By inhibiting IMPDH, Immutil S effectively depletes guanosine nucleotides within lymphocytes, thereby arresting their proliferation and suppressing the cellular and humoral immune responses that are responsible for graft rejection. This targeted immunosuppression helps to prevent the recipient's immune system from attacking and damaging the transplanted organ. It is typically administered as part of a multi-drug immunosuppressive regimen, often in combination with corticosteroids and calcineurin inhibitors, to achieve optimal immune suppression while minimizing the overall toxicity and side effects associated with high doses of individual agents, thereby enhancing long-term graft survival and patient quality of life.

Uses

• Prevention of organ rejection in kidney transplant patients.
• Prevention of organ rejection in heart transplant patients.
• Prevention of organ rejection in liver transplant patients.
• Treatment of certain autoimmune diseases (off-label use).

Directions For Use

Take orally on an empty stomach, usually twice daily. Do not crush or chew the tablets.

Benefits

• Effectively prevents organ transplant rejection.
• Reduces the need for high doses of corticosteroids.
• Improves long-term graft survival rates.
• Available in a convenient oral tablet form.
• Part of a comprehensive immunosuppressive regimen.
• Helps maintain the function of transplanted organs.

Side Effects

• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Leukopenia (low white blood cell count)
• Anemia (low red blood cell count)
• Thrombocytopenia (low platelet count)
• Increased risk of infections
• Increased risk of certain cancers (lymphoma)
• Headache
• Hypertension (high blood pressure)
• Peripheral edema
• Insomnia

Safety Measures

• Alcohol - Alcohol may increase the risk of gastrointestinal side effects; use with caution.
• Pregnancy - Contraindicated in pregnancy due to high risk of birth defects and miscarriage. Effective contraception is essential.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant.
• Liver - Use with caution in severe liver impairment; dose adjustments may be necessary.
• Kidney - Dose adjustments may be required in patients with severe renal impairment.
• Lung - May rarely cause interstitial lung disease; monitor for new or worsening respiratory symptoms.

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