Mycept S 360mg Tablet

About

Mycept S (mycophenolate sodium) is an immunosuppressant medication primarily used to prevent organ rejection in patients who have received kidney, heart, or liver transplants. It is an enteric-coated salt of mycophenolic acid, acting as a prodrug that is converted to its active form, mycophenolic acid (MPA), in the body. MPA selectively inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme critical for the de novo synthesis of guanosine nucleotides. This inhibition leads to a profound suppression of T and B lymphocyte proliferation, which are key immune cells responsible for mediating the rejection of transplanted organs. The enteric coating helps reduce gastrointestinal side effects, enhancing patient comfort and compliance with the prescribed regimen, making it a valuable option in long-term immunosuppressive therapy.

Uses

• Prevention of kidney transplant rejection
• Prevention of heart transplant rejection
• Prevention of liver transplant rejection
• Treatment of certain autoimmune diseases (off-label)

Directions For Use

Take orally, usually twice daily, on an empty stomach. Do not crush, chew, or break the tablet.

Benefits

• Effectively prevents acute organ rejection episodes
• Improves long-term graft survival rates
• Allows for reduced doses of calcineurin inhibitors
• Targeted immunosuppression of lymphocytes
• Enteric coating reduces GI side effects
• Well-established efficacy in transplant protocols

Side Effects

• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Leukopenia (low white blood cell count)
• Anemia (low red blood cell count)
• Thrombocytopenia (low platelet count)
• Increased risk of infections
• Increased risk of certain cancers (e.g., lymphoma, skin cancer)
• Hypertension
• Headache
• Tremor
• Insomnia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or increase liver strain.
• Pregnancy - Mycept S is highly teratogenic and contraindicated in pregnancy due to severe birth defects. Effective contraception is mandatory.
• Breastfeeding - Not recommended during breastfeeding as mycophenolic acid can pass into breast milk and potentially harm the infant.
• Liver - Use with caution in patients with severe liver impairment; dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Use with caution in patients with severe kidney impairment; dose adjustments may be necessary, and kidney function should be monitored.
• Lung - Monitor for new or worsening respiratory symptoms as interstitial lung disease is a known, though rare, adverse effect.

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