TELVAS LN 40 10S

About

Telmisartan/Cilnidipine, marketed as Telvas LN, is a combination medication primarily used for the treatment of essential hypertension. Telmisartan is an angiotensin II receptor blocker (ARB) that selectively blocks the binding of angiotensin II to the AT1 receptor. This action leads to vasodilation, reduced aldosterone secretion, and ultimately, a decrease in blood pressure. Cilnidipine is a dihydropyridine calcium channel blocker (CCB) that inhibits the influx of calcium ions into vascular smooth muscle cells, resulting in peripheral vasodilation and a reduction in systemic vascular resistance. This dual mechanism provides comprehensive blood pressure control by addressing both the renin-angiotensin system and calcium channels. The combination often leads to more effective and sustained antihypertensive effects, and cilnidipine is noted for potentially reducing the incidence of CCB-related peripheral edema compared to other CCBs.

Uses

• Treatment of essential hypertension.
• To achieve better blood pressure control in patients.
• When monotherapy is insufficient for hypertension.
• To reduce cardiovascular risk associated with high blood pressure.

Directions For Use

Take orally once daily, preferably at the same time each day, with or without food, as directed by your doctor.

Benefits

• Provides effective and sustained blood pressure reduction.
• Combines two complementary antihypertensive mechanisms.
• May reduce CCB-related peripheral edema.
• Offers cardiovascular protection.
• Convenient once-daily dosing.
• Suitable for patients needing dual therapy.

Side Effects

• Dizziness
• Headache
• Fatigue
• Hypotension (low blood pressure)
• Peripheral edema (less common than with other CCBs)
• Flushing
• Nausea
• Diarrhea
• Cough (less common than with ACE inhibitors)
• Hyperkalemia (rare, due to telmisartan)
• Renal impairment (rare)
• Palpitations

Safety Measures

• Alcohol - Alcohol may enhance the hypotensive effects; use with caution and avoid excessive intake.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm from telmisartan (renal dysfunction, oligohydramnios).
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and harm the infant.
• Liver - Use with caution in hepatic impairment; dose adjustment may be necessary, especially for telmisartan.
• Kidney - Use with caution in renal impairment; monitor kidney function and potassium levels regularly.
• Lung - Generally safe for use in patients with lung conditions; no specific pulmonary contraindications.

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