CILACAR M 10/25MG 10'S

About

Cilacar M 10/25mg represents a synergistic fixed-dose combination therapy, integrating Cilnidipine, a dihydropyridine calcium channel blocker, with Metoprolol, a beta-1 selective adrenergic blocker. This formulation is specifically designed for the comprehensive and robust management of essential hypertension, particularly in patients whose blood pressure remains inadequately controlled with monotherapy. Cilnidipine contributes by inducing peripheral vasodilation through calcium channel blockade, thereby reducing systemic vascular resistance. Concurrently, Metoprolol acts to decrease heart rate, reduce cardiac output, and inhibit renin release, further contributing to blood pressure reduction. The combined action of these two agents targets multiple physiological pathways involved in hypertension, providing a more profound and sustained antihypertensive effect, improving overall cardiovascular outcomes, and enhancing patient adherence through simplified dosing regimens.

Uses

• Treatment of essential hypertension.
• Management of high blood pressure not controlled by monotherapy.
• Reduction of cardiovascular risk in hypertensive patients.
• Used when both calcium channel blockade and beta-blockade are indicated.

Directions For Use

Take this medication orally, usually once daily, with or without food, as directed by your physician. Do not crush or chew the tablet.

Benefits

• Comprehensive blood pressure control.
• Synergistic action of two antihypertensive classes.
• Effective in resistant hypertension.
• Reduces heart rate and vascular resistance.
• Convenient once-daily dosing.
• May improve patient adherence.

Side Effects

• Dizziness
• Headache
• Fatigue
• Bradycardia
• Peripheral edema
• Nausea
• Cold extremities
• Orthostatic hypotension
• Bronchospasm (rare)
• Sleep disturbances
• Depression
• Sexual dysfunction

Safety Measures

• Alcohol - Alcohol can enhance the hypotensive effects and increase the risk of dizziness or drowsiness. It is advisable to limit or avoid alcohol consumption.
• Pregnancy - This combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
• Breastfeeding - Both cilnidipine and metoprolol may be excreted in breast milk. Caution is advised, and a doctor's advice should be sought before use during breastfeeding.
• Liver - Use with caution in patients with hepatic impairment, as metabolism of both components may be affected. Dosage adjustment may be necessary.
• Kidney - Use with caution in patients with severe renal impairment. Dosage adjustments may be required, and close monitoring of renal function is recommended.
• Lung - Metoprolol, even if beta-1 selective, should be used with caution in patients with bronchospastic diseases (e.g., asthma, COPD) as it may worsen respiratory symptoms.

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