TENIVA TAB 20.S

About

DPP-4 inhibitors, such as Teneligliptin, represent a significant class of oral antidiabetic drugs specifically designed for the effective management of type 2 diabetes mellitus. Their therapeutic action is centered on inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which plays a crucial role in the rapid inactivation of incretin hormones, namely Glucagon-Like Peptide-1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP). By preventing the enzymatic breakdown of these vital incretins, DPP-4 inhibitors lead to a sustained increase in their active concentrations. This elevation in incretin levels subsequently enhances glucose-dependent insulin secretion from the pancreatic beta cells, thereby improving the body's ability to respond to rising blood sugar. Concurrently, they reduce glucagon secretion from pancreatic alpha cells, which helps to decrease hepatic glucose output. This dual action effectively lowers both fasting and post-meal blood glucose levels. A notable advantage of DPP-4 inhibitors is their generally favorable safety profile, characterized by a low risk of hypoglycemia when used alone and a weight-neutral effect, making them a valuable option for many patients.

Uses

• Treatment of type 2 diabetes mellitus.
• Used as monotherapy or in combination with other antidiabetic agents.
• To improve glycemic control in adults.
• Suitable for patients who cannot tolerate metformin or have contraindications.

Directions For Use

Take orally once daily, with or without food, as prescribed by your physician.

Benefits

• Effectively lowers blood glucose levels.
• Low risk of hypoglycemia.
• Weight-neutral effect.
• Well-tolerated with a favorable safety profile.
• Can be used in patients with renal impairment (dose adjustment may be needed for some).
• Convenient once-daily dosing.

Side Effects

• Nasopharyngitis
• Headache
• Upper respiratory tract infection
• Urinary tract infection
• Diarrhea
• Constipation
• Abdominal pain
• Hypoglycemia (when used with sulfonylureas or insulin)
• Pancreatitis (rare)
• Joint pain (arthralgia)
• Skin reactions (e.g., rash, urticaria)
• Angioedema (rare)

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake should be avoided as it can affect blood sugar levels.
• Pregnancy - Consult your doctor. Limited data on use during pregnancy; generally not recommended unless potential benefits outweigh risks.
• Breastfeeding - It is unknown if it passes into breast milk. Use with caution and only if clearly necessary, after consulting a healthcare professional.
• Liver - Generally safe, but use with caution in patients with severe hepatic impairment. No dose adjustment typically required for mild to moderate impairment.
• Kidney - Dose adjustment may be required for some DPP-4 inhibitors in patients with moderate to severe renal impairment. Consult your doctor.
• Lung - Generally safe for use in patients with lung conditions. No specific precautions related to lung function.

Disclaimer

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