ZITEN M 20/1000 TAB 10 S

About

ZITEN M 20/1000 TAB is a potent combination oral antidiabetic medication containing Teneligliptin 20mg and Metformin 1000mg, indicated for the comprehensive management of Type 2 Diabetes Mellitus. Teneligliptin, a DPP-4 inhibitor, works by enhancing the body's natural ability to lower blood glucose by increasing active incretin hormone levels, which in turn boosts glucose-dependent insulin secretion and suppresses glucagon release. Metformin, a biguanide, complements this action by significantly reducing hepatic glucose production and improving insulin sensitivity in peripheral tissues, thereby facilitating glucose uptake and utilization.

This higher-dose combination is particularly suitable for patients who require more intensive glycemic control and have not achieved target blood sugar levels with lower doses of antidiabetic agents or monotherapy. By addressing multiple facets of glucose dysregulation, ZITEN M 20/1000 effectively lowers both fasting and post-prandial blood glucose, leading to a substantial reduction in HbA1c. This helps in preventing the progression of diabetes and reducing the risk of associated macrovascular and microvascular complications, contributing to improved long-term health outcomes.

Uses

• Management of Type 2 Diabetes Mellitus.
• When lower doses of antidiabetics are insufficient.
• To achieve more intensive glycemic control.
• To improve glycemic control and reduce HbA1c.

Directions For Use

Take orally with meals, usually once or twice daily, as directed by your physician. Swallow the tablet whole without crushing or chewing.

Benefits

• Provides robust dual mechanism for superior glucose control.
• Significantly reduces HbA1c levels for long-term management.
• Low risk of hypoglycemia (due to Teneligliptin component).
• Helps prevent severe long-term diabetes complications.
• Weight neutral or potential for modest weight loss (due to Metformin).
• Convenient dosing for enhanced patient adherence.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Metallic taste in mouth
• Lactic acidosis (rare, serious, due to Metformin)
• Headache
• Dizziness
• Nasopharyngitis (common cold symptoms)
• Pancreatitis (rare, due to Teneligliptin)
• Skin rash
• Constipation
• Vitamin B12 deficiency (long-term Metformin use)
• Dyspepsia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to increased risk of lactic acidosis with Metformin.
• Pregnancy - Generally not recommended during pregnancy; insulin is usually preferred. Consult your doctor immediately if pregnant or planning pregnancy.
• Breastfeeding - Not recommended during breastfeeding as Metformin passes into breast milk. Consult your doctor.
• Liver - Use with caution in moderate hepatic impairment; contraindicated in severe hepatic impairment due to Metformin.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to Metformin accumulation and risk of lactic acidosis.
• Lung - Use with caution in severe respiratory conditions that may predispose to hypoxia and increase the risk of lactic acidosis.

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