TIBAN M 20/1000 10 S

About

TIBAN M 20/1000 is a combination medication prescribed for the management of type 2 diabetes mellitus, featuring Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin, a biguanide. Teneligliptin enhances the body's natural ability to lower blood glucose by increasing active incretin hormone levels, which promote insulin secretion and reduce glucagon release in a glucose-dependent manner. Metformin works primarily by decreasing glucose production in the liver, reducing glucose absorption from the intestines, and improving insulin sensitivity in peripheral tissues.

This fixed-dose combination is particularly useful for patients who have not achieved adequate glycemic control with monotherapy or lower doses of combination therapy. It offers a synergistic approach to managing blood sugar, helping to achieve target HbA1c levels and mitigate the long-term complications associated with uncontrolled diabetes, thereby improving patient outcomes.

Uses

• Treatment of type 2 diabetes mellitus.
• To improve glycemic control in adults.
• Adjunct to diet and exercise regimen.
• When lower strength combinations are insufficient.

Directions For Use

Take this medicine orally with meals, as prescribed by your doctor, to minimize potential gastrointestinal upset.

Swallow the tablet whole with a glass of water; do not chew, crush, or break it.

Benefits

• Provides robust blood glucose reduction.
• Targets both fasting and post-meal glucose.
• Synergistic action of two antidiabetic agents.
• Helps achieve and maintain HbA1c goals.
• Offers a convenient, single-tablet regimen.
• May contribute to weight stability or modest loss.

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Abdominal discomfort
• Headache
• Dizziness
• Hypoglycemia (especially with other antidiabetics)
• Metallic taste
• Upper respiratory infection
• Nasopharyngitis
• Lactic acidosis (rare, serious)
• Vitamin B12 deficiency

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can significantly increase the risk of lactic acidosis, a severe complication associated with metformin.
• Pregnancy - Generally not recommended during pregnancy. Consult your doctor to discuss risks and benefits if you are pregnant or planning to conceive.
• Breastfeeding - Metformin passes into breast milk. Teneligliptin's presence in breast milk is unknown. Use with caution and medical advice.
• Liver - Exercise caution in patients with hepatic impairment. Severe liver dysfunction is a contraindication for metformin due to increased lactic acidosis risk.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to the risk of metformin accumulation and lactic acidosis.
• Lung - No specific contraindications, but conditions causing hypoxia (e.g., severe lung disease) can increase the risk of lactic acidosis.

Disclaimer

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