Introduction to Toritz 500mg Injection

Toritz 500mg Injection contains rituximab, a monoclonal antibody used to treat several conditions related to abnormal B-lymphocytes. It is prescribed either alone or in combination with other therapies for adults diagnosed with Non-Hodgkin’s Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)—types of cancers affecting B-cells.

It is also approved for treating moderate to severe Rheumatoid Arthritis (as part of combination therapy with methotrexate), and certain autoimmune vasculitis conditions such as Granulomatosis with Polyangiitis and Microscopic Polyangiitis in adults and children above 2 years. In addition, Toritz is used to manage moderate to severe Pemphigus Vulgaris, an autoimmune disorder that causes painful skin and mucosal blisters.

Toritz 500mg belongs to the class of anti-CD20 monoclonal antibodies, which target B-cells that carry the CD20 antigen. You should avoid this medication if you are allergic to rituximab, have severe infections, or if your immune system is weakened. Inform your doctor if you have heart-related issues, breathing problems, or a history of Hepatitis B infection, as the virus may reactivate during therapy.

This medicine is not recommended during pregnancy or breastfeeding.

Common side effects include infections, anemia, facial swelling, itching, diarrhea, sweating, dizziness, and changes in blood pressure. Some patients may experience infusion-related reactions within 24 hours of administration. Contact your healthcare provider immediately if you develop chest pain, difficulty breathing, rash, vomiting, headache, or throat swelling.

Uses of Toritz 500mg Injection

• Non-Hodgkin’s Lymphoma (NHL)

• Chronic Lymphocytic Leukemia (CLL)

• Rheumatoid Arthritis

• Granulomatosis with Polyangiitis

• Microscopic Polyangiitis

• Pemphigus Vulgaris

How Toritz 500mg Injection Works

Toritz 500mg Injection targets CD20, a protein present on the surface of B-lymphocytes. By binding to this antigen, the medicine leads to the destruction of abnormal B-cells in NHL and CLL.

In rheumatoid arthritis, it helps reduce inflammation by lowering rheumatoid factor production, preventing T-cell activation, and reducing inflammatory cytokines. This action helps improve joint symptoms and slow disease progression.

Drug Interactions

Inform your doctor about all medications you take—prescription, OTC, herbal supplements, and vitamins. Particular caution is needed if you are taking medicines for blood pressure, heart problems, or immunosuppressive medications.
Some drugs may interact with Toritz 500mg and increase the risk of side effects or reduce its effectiveness.

Storage Instructions

• Store in a refrigerator between 2°C and 8°C

• Do not freeze

• Keep away from children and pets

• If you miss a scheduled dose, inform your doctor immediately

How Toritz 500mg Injection Is Administered

This injection is given only by a trained healthcare professional through intravenous infusion. Do not administer it yourself.
Pre-medication may be given to prevent infusion reactions. The dosing schedule depends on your condition and medical history. You will be monitored closely during and after the infusion for any adverse reactions.

Safety Advice

Breastfeeding – Not Safe

Toritz may pass into breast milk and harm the infant. Breastfeeding should be avoided during treatment.

Alcohol – Not Recommended

Alcohol may interfere with treatment effectiveness. Avoid alcohol consumption.

Liver – Use with Caution

Safety in liver-disease patients is uncertain. If you have liver disorders or a history of Hepatitis B, inform your doctor as reactivation is possible.

Lungs – Use with Caution

Patients with existing lung diseases should consult their doctor before receiving this injection.

Driving – Unsafe

The medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery.

Pregnancy – Unsafe

Toritz is not recommended during pregnancy. Use reliable contraception during treatment and for 12 months after your last dose.

Possible Side Effects of Toritz 500mg Injection

Common Side Effects

• Facial or body swelling

• Nausea, diarrhea

• Itching

• Anemia

• Fever, chills

• Nasal inflammation

• Hair loss

• Headache

• Urinary tract infection

• Muscle spasms

• Cough or sore throat

Serious Side Effects

• High or low blood pressure

• Chest pain

• Severe allergic or infusion reactions

• Hepatitis B reactivation

• Neurological changes such as memory issues or difficulty walking

Seek immediate medical attention if you experience severe reactions.

Important Advice

Avoid receiving live vaccines before, during, or shortly after treatment. Toritz can weaken the immune system, reducing vaccine effectiveness and increasing infection risk.

Report symptoms like chest pain, breathing issues, abdominal pain, severe rashes, or signs of infection to your doctor promptly.

There is limited data on its use in patients with kidney disease—inform your physician if you have any renal problems.

Disclaimer

Medehub aims to provide medically accurate, reliable, and updated information. The content above is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance regarding any medicine or medical condition. Medehub’s goal is to complement—not replace—the relationship between patients and healthcare professionals.