Uromitexan 200mg Injection

About

Uromitexan 200mg Injection, containing Mesna (2-mercaptoethane sulfonate sodium), is a uroprotective agent specifically designed to prevent hemorrhagic cystitis, a severe bladder inflammation caused by certain oxazaphosphorine chemotherapeutic agents like ifosfamide and cyclophosphamide. These drugs are metabolized in the body to acrolein, a highly toxic metabolite that irritates the bladder lining. Mesna works by selectively concentrating in the bladder, where it detoxifies acrolein through a chemical reaction, forming a non-toxic conjugate that is then excreted.

It also provides a sulfhydryl group that can scavenge free radicals, further protecting the urothelium from oxidative damage. The administration of Mesna is crucial when using high doses of ifosfamide or cyclophosphamide to ensure the safety and tolerability of these potent anticancer drugs, thereby allowing for effective chemotherapy without compromising bladder integrity. Adequate hydration is also typically recommended alongside Mesna administration.

Uses

• Prevention of hemorrhagic cystitis induced by ifosfamide.
• Prevention of hemorrhagic cystitis induced by cyclophosphamide.
• Used in high-dose chemotherapy regimens.
• Protection of the urinary tract during specific cancer treatments.

Directions For Use

Administered intravenously, typically in conjunction with ifosfamide or cyclophosphamide, as directed by a physician.

Benefits

• Prevents severe bladder toxicity.
• Allows for higher doses of chemotherapy.
• Reduces risk of hemorrhagic cystitis.
• Improves patient tolerance to chemotherapy.
• Essential for specific cancer treatments.
• Protects the urinary tract.

Side Effects

• Nausea and vomiting.
• Diarrhea.
• Headache.
• Dizziness.
• Fatigue.
• Flushing.
• Injection site reactions.
• Abdominal pain.
• Rash.
• Hypotension (rare).
• Bronchospasm (rare).
• Allergic reactions (rare).

Safety Measures

• Alcohol - No specific contraindication, but avoid excessive alcohol during chemotherapy treatment.
• Pregnancy - Use only if clearly needed and potential benefits outweigh risks; consult a physician.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it passes into breast milk.
• Liver - Use with caution in patients with severe hepatic impairment; monitor for adverse effects.
• Kidney - Use with caution in patients with renal impairment; monitor kidney function and ensure adequate hydration.
• Lung - Rare reports of bronchospasm; use with caution in patients with asthma or reactive airway disease.

Disclaimer

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