Xtandi 40mg Capsule

About

Xtandi (enzalutamide) is an oral androgen receptor inhibitor used for the treatment of prostate cancer. It works by targeting multiple steps in the androgen receptor signaling pathway, which is critical for the growth and survival of prostate cancer cells. Specifically, enzalutamide inhibits androgen binding to the androgen receptor, prevents androgen receptor nuclear translocation, and impairs DNA binding and transcription of androgen-responsive genes. This comprehensive blockade of androgen signaling helps to suppress tumor growth and progression, offering a significant therapeutic option for patients.

Xtandi is indicated for patients with metastatic castration-resistant prostate cancer (mCRPC), non-metastatic castration-resistant prostate cancer (nmCRPC), and metastatic hormone-sensitive prostate cancer (mHSPC). It is administered orally, providing a convenient treatment modality. Patients undergoing treatment with Xtandi require regular monitoring for efficacy and potential side effects, including fatigue, hypertension, and rare but serious events like seizures. Adherence to the prescribed dosage and schedule is vital for optimal therapeutic outcomes and managing the disease effectively.

Uses

• Treatment of metastatic castration-resistant prostate cancer (mCRPC)
• Management of non-metastatic castration-resistant prostate cancer (nmCRPC)
• Therapy for metastatic hormone-sensitive prostate cancer (mHSPC)
• Used in conjunction with androgen deprivation therapy

Directions For Use

Take orally, usually once daily, with or without food. Swallow the capsule whole; do not chew or crush.

Benefits

• Delays disease progression in prostate cancer
• Improves overall survival in advanced stages
• Reduces the risk of skeletal-related events
• Convenient oral administration
• Effective in castration-resistant settings
• Offers a targeted approach to cancer therapy

Side Effects

• Fatigue
• Hot flashes
• Hypertension
• Seizures (rare)
• Falls
• Headache
• Diarrhea
• Musculoskeletal pain
• Peripheral edema
• Decreased appetite
• Dizziness
• Nausea

Safety Measures

• Alcohol - No specific interaction with alcohol is known, but general health advice to limit alcohol intake applies.
• Pregnancy - Contraindicated in pregnant women due to potential for fetal harm. Women of childbearing potential should avoid contact with Xtandi.
• Breastfeeding - Not indicated for use in women.
• Liver - Use with caution in patients with severe hepatic impairment; dose adjustment may be necessary. Monitor liver function regularly.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustment may be necessary. Monitor kidney function regularly.
• Lung - No specific lung toxicity is commonly associated, but monitor for any new or worsening respiratory symptoms.

Disclaimer

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