ZORYL MV 2MG 10S

About

ZORYL MV 2MG is an oral antidiabetic medication, typically a combination of Glimepiride and Metformin, used in the management of Type 2 Diabetes Mellitus. Glimepiride, a sulfonylurea, works by stimulating the beta cells in the pancreas to release more insulin, thereby lowering blood glucose levels. Metformin, a biguanide, acts primarily by reducing glucose production in the liver and improving the body's sensitivity to insulin, allowing cells to absorb more glucose from the blood. This dual mechanism of action provides comprehensive glycemic control, addressing different aspects of insulin resistance and deficiency.

The combination therapy is particularly effective for patients whose blood sugar levels are not adequately controlled by diet, exercise, or monotherapy with either Glimepiride or Metformin alone. By targeting multiple pathways involved in glucose regulation, ZORYL MV helps to achieve and maintain optimal blood glucose levels, reduce HbA1c, and mitigate the risk of long-term diabetic complications such as cardiovascular disease, neuropathy, and nephropathy. It is an important tool in a holistic diabetes management plan.

Uses

• Management of Type 2 Diabetes Mellitus.
• When diet and exercise alone are insufficient.
• When monotherapy with Glimepiride or Metformin is inadequate.
• To improve glycemic control and reduce HbA1c.

Directions For Use

Take orally with meals, usually once or twice daily, as directed by your physician. Swallow the tablet whole without crushing or chewing.

Benefits

• Provides dual mechanism for effective glucose control.
• Significantly reduces HbA1c levels.
• Helps prevent long-term diabetes complications.
• Improves insulin sensitivity and reduces hepatic glucose output.
• Convenient dosing for better patient adherence.
• Potential for weight neutrality or modest weight loss (due to Metformin).

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Metallic taste in mouth
• Lactic acidosis (rare, serious, due to Metformin)
• Headache
• Dizziness
• Skin rash
• Weight gain (due to Glimepiride)
• Vitamin B12 deficiency (long-term Metformin use)
• Dyspepsia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to increased risk of hypoglycemia and lactic acidosis, especially with Metformin.
• Pregnancy - Generally not recommended during pregnancy; insulin is usually preferred. Consult your doctor immediately if pregnant or planning pregnancy.
• Breastfeeding - Not recommended during breastfeeding as Metformin passes into breast milk. Consult your doctor.
• Liver - Contraindicated in severe hepatic impairment due to increased risk of lactic acidosis with Metformin. Use with caution in moderate impairment.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to Metformin accumulation and risk of lactic acidosis.
• Lung - Use with caution in severe respiratory conditions that may predispose to hypoxia and increase the risk of lactic acidosis.

Disclaimer

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