About

Abiraterone is a potent androgen biosynthesis inhibitor, specifically indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC) and high-risk metastatic castration-sensitive prostate cancer. Its mechanism of action involves the selective inhibition of cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17), an enzyme critical for androgen production in the testes, adrenal glands, and prostate tumor tissue itself. By blocking this enzyme, abiraterone significantly reduces the synthesis of androgens, which are hormones that fuel the growth of prostate cancer cells. This comprehensive reduction in androgen levels helps to suppress tumor progression, alleviate disease symptoms, and significantly improve overall survival and progression-free survival in men with advanced prostate cancer, particularly when used in combination with prednisone.

Uses

Treatment of metastatic castration-resistant prostate cancer.
Used in combination with prednisone.
Management of high-risk metastatic castration-sensitive prostate cancer.
Reduces androgen production in prostate cancer.

Directions For Use

Take four tablets once daily on an empty stomach, at least 1 hour before or 2 hours after food.

Benefits

Effective in advanced prostate cancer.
Significantly reduces androgen levels.
Can prolong overall survival.
Improves progression-free survival.
Oral administration for patient convenience.
Well-established efficacy in mCRPC.

Side Effects

Fatigue
Joint swelling (edema)
Hot flashes
Diarrhea
Nausea
Vomiting
High blood pressure (hypertension)
Hypokalemia (low potassium)
Liver enzyme elevation
Urinary tract infection
Cough
Muscle discomfort

Safety Measures

Alcohol - Avoid or limit alcohol, as it may increase the risk of liver toxicity.
Pregnancy - Contraindicated for women who are pregnant or may become pregnant, as it can cause fetal harm.
Breastfeeding - Not applicable as it's for prostate cancer, but generally not recommended for women.
Liver - Use with caution and potential dose adjustment in patients with moderate to severe liver impairment; monitor liver function.
Kidney - Use with caution in patients with severe kidney impairment; monitor renal function closely.
Lung - Generally safe for lung conditions; no specific lung-related precautions are typically needed.

Disclaimer

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