Abtmed 250mg Tablet

About

Abtmed 250mg Tablet contains Abiraterone acetate, an androgen biosynthesis inhibitor used in the treatment of metastatic castration-resistant prostate cancer (mCRPC). Prostate cancer growth is often driven by androgens. Abiraterone works by inhibiting cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumor tissues, which is crucial for androgen biosynthesis. By blocking CYP17, Abiraterone significantly reduces the production of androgens, including testosterone, both in the testes and adrenal glands, thereby slowing the progression of prostate cancer.

This oral medication is typically administered in combination with prednisone or prednisolone to manage mineralocorticoid excess, a common side effect due to the inhibition of CYP17. Abiraterone has demonstrated significant improvements in overall survival and progression-free survival in patients with mCRPC, both before and after chemotherapy. Its mechanism of action provides a critical therapeutic option for patients whose cancer has become resistant to traditional androgen deprivation therapy. Regular monitoring of blood pressure, potassium levels, and liver function is essential during treatment.

Uses

• Metastatic castration-resistant prostate cancer (mCRPC)
• Metastatic high-risk castration-sensitive prostate cancer (mCSPC)
• Prostate cancer progression after androgen deprivation therapy
• Hormone-sensitive prostate cancer (in combination with ADT)

Directions For Use

Take orally on an empty stomach, at least one hour before or two hours after food. Administer with prednisone/prednisolone as directed by your doctor.

Benefits

• Inhibits androgen production effectively.
• Improves overall survival in mCRPC.
• Delays disease progression.
• Oral administration for convenience.
• Effective in both pre- and post-chemotherapy settings.
• Offers a targeted approach to prostate cancer.

Side Effects

• Fatigue
• Fluid retention (edema)
• Hypertension
• Hypokalemia
• Liver enzyme elevation
• Diarrhea
• Urinary tract infection
• Hot flashes
• Joint swelling/discomfort
• Cardiac disorders (e.g., arrhythmia)
• Adrenal insufficiency
• Hypertriglyceridemia

Safety Measures

• Alcohol - Avoid alcohol as it may increase the risk of liver toxicity and other adverse effects, potentially interfering with treatment efficacy.
• Pregnancy - Abiraterone is contraindicated in pregnant women due to potential harm to the fetus. Women of childbearing potential should avoid handling this medication without gloves.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after the last dose, as the drug may pass into breast milk and harm the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are often required. Close and regular monitoring of liver function tests is critical.
• Kidney - Use with caution in patients with renal impairment. No specific dose adjustment is typically needed for mild-to-moderate impairment, but monitoring is advised.
• Lung - Monitor for signs of pulmonary toxicity, though less common, especially in patients with pre-existing lung conditions.

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