AMLOSAFE TM 40 TAB 10 S

About

AMLOSAFE TM 40 TAB 10 S contains Amlodipine, a dihydropyridine calcium channel blocker widely used for the treatment of hypertension and angina pectoris. Amlodipine works by inhibiting the influx of calcium ions into vascular smooth muscle and myocardial cells. This action leads to peripheral arterial vasodilation, which reduces peripheral vascular resistance and consequently lowers blood pressure. In patients with angina, it increases myocardial oxygen delivery by dilating coronary arteries and reduces myocardial oxygen demand by decreasing afterload.

Amlodipine is characterized by its long duration of action, allowing for once-daily dosing, and its gradual onset of action, which minimizes the risk of reflex tachycardia. It is an effective and well-tolerated agent for long-term management of cardiovascular conditions.

Uses

• Treatment of essential hypertension.
• Management of chronic stable angina.
• Treatment of vasospastic angina (Prinzmetal's angina).
• Reduction of cardiovascular events in hypertensive patients.

Directions For Use

Take one tablet orally once daily, with or without food, as directed by your physician.

Benefits

• Effective blood pressure control.
• Reduces frequency and severity of angina attacks.
• Long-acting, once-daily dosing.
• Well-tolerated in most patients.
• Minimal reflex tachycardia.
• Can be used in patients with diabetes or renal impairment.

Side Effects

• Peripheral edema
• Headache
• Dizziness
• Fatigue
• Flushing
• Palpitations
• Nausea
• Abdominal pain
• Somnolence
• Gingival hyperplasia
• Muscle cramps
• Rash

Safety Measures

• Alcohol - Alcohol may enhance the hypotensive effects of amlodipine and increase the risk of dizziness or lightheadedness. It is advisable to limit alcohol consumption.
• Pregnancy - Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited data suggest no increased risk of major birth defects.
• Breastfeeding - Amlodipine is excreted in human milk. While the amount is small, caution is advised, and the infant should be monitored for hypotension or sedation.
• Liver - Use with caution in patients with hepatic impairment, as the elimination half-life of amlodipine is prolonged. Dose adjustments may be necessary.
• Kidney - Amlodipine is extensively metabolized by the liver, with minimal renal excretion. No dose adjustment is typically required in patients with renal impairment.
• Lung - Generally safe for use in patients with lung conditions, as it does not directly affect respiratory function.

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