About
Cabaxan is an antineoplastic agent belonging to the taxane class, primarily utilized in the treatment of various advanced cancers. Its mechanism of action involves disrupting the microtubule network within cancer cells, which is essential for cell division and other vital cellular processes. Specifically, Cabaxan binds to tubulin, promoting its assembly into stable microtubules while simultaneously inhibiting their disassembly. This action leads to the stabilization of microtubules, preventing the dynamic reorganization necessary for mitotic and interphase cellular functions.
Consequently, cancer cells become arrested in the G2/M phase of the cell cycle, ultimately triggering programmed cell death (apoptosis). Its efficacy is particularly noted in hormone-refractory metastatic prostate cancer, often after prior docetaxel treatment, due to its ability to overcome certain resistance mechanisms and provide a crucial therapeutic option.
Uses
- Treatment of metastatic castration-resistant prostate cancer (mCRPC).
- Used after prior docetaxel-containing treatment regimen.
- Under investigation for other solid tumors.
- Part of combination chemotherapy protocols.
Directions For Use
Administered intravenously by a healthcare professional. Dosage and frequency are determined by your doctor based on your condition.
Benefits
- Effective in advanced prostate cancer.
- Useful in patients resistant to other taxanes.
- Can prolong survival in mCRPC.
- Offers a treatment option for refractory disease.
- Administered under medical supervision.
- Part of established chemotherapy regimens.
Side Effects
- Bone marrow suppression (neutropenia)
- Fatigue
- Nausea
- Diarrhea
- Vomiting
- Peripheral neuropathy
- Anemia
- Thrombocytopenia
- Hypersensitivity reactions
- Abdominal pain
- Hair loss (alopecia)
- Constipation
Safety Measures
- Alcohol - Avoid alcohol during treatment as it may worsen side effects like nausea or fatigue and could interact with the medication's metabolism.
- Pregnancy - Contraindicated in pregnancy due to significant risk of fetal harm. Women of childbearing potential must use effective contraception.
- Breastfeeding - Not recommended during breastfeeding due to the potential for serious adverse effects in the infant. Discontinue breastfeeding.
- Liver - Use with extreme caution in patients with hepatic impairment; dose reduction or discontinuation may be necessary. Monitor liver function closely.
- Kidney - Use with caution in patients with severe renal impairment. Monitor kidney function and adjust dose as needed.
- Lung - Monitor for new or worsening pulmonary symptoms, including interstitial pneumonitis, which can be severe.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
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