Cadinib 400mg Tablet

About

Imatinib is a groundbreaking tyrosine kinase inhibitor that revolutionized the treatment of several cancers, most notably chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). Its highly targeted action stems from its ability to selectively inhibit the Bcr-Abl tyrosine kinase, which is the oncogenic driver in CML. By blocking this abnormal protein, imatinib prevents the uncontrolled proliferation of leukemic cells and induces apoptosis, leading to deep and durable remissions.

Beyond CML, imatinib also inhibits other receptor tyrosine kinases, including KIT and PDGFRA, which are key drivers in the pathogenesis of GIST. This targeted inhibition effectively suppresses tumor growth and survival in GIST patients. The introduction of imatinib marked a paradigm shift in cancer therapy, demonstrating the power of molecularly targeted drugs to achieve significant clinical responses with a more favorable side effect profile compared to conventional chemotherapy. It is also used in other rare conditions like myelodysplastic/myeloproliferative diseases and hypereosinophilic syndrome.

Uses

• Chronic Myeloid Leukemia (CML)
• Gastrointestinal Stromal Tumors (GIST)
• Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
• Hypereosinophilic Syndrome (HES)

Directions For Use

Take orally with a meal and a large glass of water to minimize gastrointestinal irritation.

Benefits

• Highly effective in CML and GIST
• Targeted therapy with fewer systemic side effects
• Oral administration for patient convenience
• Significantly improves survival rates
• Induces durable remissions
• Well-tolerated by many patients

Side Effects

• Fluid retention (edema)
• Nausea and vomiting
• Muscle cramps
• Diarrhea
• Fatigue
• Skin rash
• Myelosuppression
• Liver enzyme elevation
• Periorbital edema
• Abdominal pain
• Headache
• Weight gain

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm. Use effective contraception during treatment.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests closely and adjust dose as needed.
• Kidney - Use with caution in patients with severe renal impairment; dosage adjustments may be necessary.
• Lung - Monitor for potential pulmonary adverse events, including interstitial lung disease, though rare.

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