Glivec 400mg Tablet

About

Glivec 400mg Tablet contains Imatinib, a potent tyrosine kinase inhibitor that selectively targets the BCR-ABL fusion protein, a hallmark of chronic myeloid leukemia (CML), and other receptor tyrosine kinases like c-KIT and PDGF receptors. This targeted action disrupts the signaling pathways essential for the proliferation and survival of cancer cells in conditions such as CML and gastrointestinal stromal tumors (GIST). By inhibiting these specific enzymes, imatinib effectively controls disease progression, reduces tumor size, and significantly improves patient outcomes and survival rates, representing a cornerstone in the treatment of these malignancies. Its specificity minimizes damage to healthy cells compared to traditional chemotherapy, leading to a more favorable side effect profile.

Uses

• Chronic Myeloid Leukemia (CML).
• Gastrointestinal Stromal Tumors (GIST).
• Myelodysplastic/Myeloproliferative Diseases (MDS/MPD).
• Hypereosinophilic Syndrome (HES) / Chronic Eosinophilic Leukemia (CEL).

Directions For Use

Take orally with a meal and a large glass of water to minimize gastrointestinal irritation.

Benefits

• Highly effective in CML and GIST.
• Targeted therapy with fewer systemic side effects.
• Improves long-term survival rates.
• Often allows for oral administration at home.
• Reduces tumor burden significantly.
• Offers a non-chemotherapeutic option for specific cancers.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Muscle cramps
• Fluid retention (edema)
• Fatigue
• Rash
• Abdominal pain
• Headache
• Myelosuppression (low blood counts)
• Liver enzyme elevation
• Periorbital edema

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased liver toxicity and gastrointestinal irritation.
• Pregnancy - Contraindicated; can cause fetal harm. Effective contraception is required for women of childbearing potential.
• Breastfeeding - Not recommended; imatinib is excreted in breast milk and can harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustment may be necessary. Monitor liver function closely.
• Kidney - Use with caution in patients with renal impairment; dose adjustment may be necessary. Monitor renal function.
• Lung - Rare cases of interstitial lung disease or pulmonary hypertension reported; monitor for new or worsening respiratory symptoms.

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