DAJIO M 500 TAB

About

DAJIO M 500 TAB is a combination medication containing Dapagliflozin and Metformin, indicated for the management of type 2 diabetes mellitus. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that lowers blood glucose by increasing glucose excretion in the urine via the kidneys. Metformin, a biguanide, primarily reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues. This combination provides a dual mechanism of action to effectively lower blood glucose levels, offering comprehensive glycemic control. Beyond glucose lowering, Dapagliflozin also provides significant cardiovascular and renal benefits, making this medication a valuable option for patients with type 2 diabetes who may also have or be at risk for heart failure or chronic kidney disease.

Uses

• Management of type 2 diabetes mellitus
• Improvement of glycemic control
• Cardiovascular risk reduction (Dapagliflozin)
• Renal protection (Dapagliflozin)

Directions For Use

Take orally with meals, usually once or twice daily, as directed by your physician.

Benefits

• Significant reduction in HbA1c levels
• Weight loss and blood pressure reduction
• Reduced risk of major adverse cardiovascular events
• Delayed progression of kidney disease
• Improved insulin sensitivity
• Dual mechanism for effective glucose control

Side Effects

• Urinary tract infections
• Genital yeast infections
• Increased urination
• Thirst
• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Hypoglycemia (rare)
• Lactic acidosis (Metformin, rare)
• Ketoacidosis (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to an increased risk of lactic acidosis, especially with the Metformin component.
• Pregnancy - Not recommended during pregnancy; consult your doctor. Potential for adverse effects on fetal kidney development.
• Breastfeeding - Not recommended during breastfeeding; consult your doctor. Metformin is known to pass into breast milk.
• Liver - Use with caution in patients with liver conditions. Metformin is contraindicated in severe hepatic impairment.
• Kidney - Not recommended in severe renal impairment (eGFR <30 mL/min/1.73m²).
• Lung - Use with caution in patients with severe respiratory conditions due to the potential for lactic acidosis.

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