About
Zomelis D combines Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Pioglitazone, a thiazolidinedione (TZD), to enhance glycemic control in adults with type 2 diabetes mellitus. Vildagliptin works by increasing active incretin hormones, GLP-1 and GIP, which stimulate glucose-dependent insulin release and suppress glucagon secretion. Pioglitazone acts primarily by activating peroxisome proliferator-activated receptor gamma (PPARγ) in adipose tissue, skeletal muscle, and liver, thereby improving insulin sensitivity and reducing insulin resistance. This combination targets different pathways involved in glucose metabolism, offering a comprehensive approach to managing blood sugar levels. It is particularly useful for patients who require improved glycemic control beyond monotherapy or who benefit from the complementary actions of these two classes of drugs.
Uses
- Treatment of type 2 diabetes mellitus.
- Improvement of insulin sensitivity.
- Reduction of fasting and post-prandial glucose levels.
- Used when diet and exercise are insufficient.
Directions For Use
Take this medication orally, usually once daily, with or without food, as prescribed by your healthcare provider.
Benefits
- Enhances insulin sensitivity.
- Reduces both fasting and post-meal glucose.
- Low risk of hypoglycemia (when used alone).
- Targets multiple diabetes pathways.
- May improve lipid profiles.
- Convenient once-daily dosing.
Side Effects
- Headache
- Dizziness
- Peripheral edema (fluid retention)
- Weight gain
- Upper respiratory tract infection
- Nasal congestion
- Bone fractures (with Pioglitazone)
- Macular edema (rare, with Pioglitazone)
- Heart failure (rare, with Pioglitazone)
- Pancreatitis (rare, with Vildagliptin)
- Skin reactions
- Hypoglycemia (if combined with sulfonylurea/insulin)
Safety Measures
- Alcohol - Moderate alcohol intake is generally acceptable, but excessive consumption should be avoided as it can affect blood sugar levels.
- Pregnancy - Not recommended during pregnancy. Consult a doctor; potential risks to the fetus.
- Breastfeeding - Avoid during breastfeeding as components may pass into breast milk. Seek medical advice.
- Liver - Contraindicated in active liver disease. Liver function tests should be monitored before and during treatment.
- Kidney - Generally safe for use in patients with kidney conditions, but caution is advised in severe impairment.
- Lung - Use with caution in patients with a history of heart failure or pulmonary edema, as Pioglitazone can exacerbate fluid retention.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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| Shop Location | Assam, India |
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