About
Justoza M combines two distinct antidiabetic agents: Dapagliflozin and Metformin, offering a synergistic approach to managing type 2 diabetes. Dapagliflozin, an SGLT2 inhibitor, reduces blood glucose by increasing its excretion in the urine, independent of insulin. Metformin, a biguanide, primarily works by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues, thereby enhancing glucose uptake and utilization. This dual mechanism provides comprehensive glycemic control, addressing both insulin resistance and glucose overproduction. The combination not only lowers HbA1c effectively but also offers additional benefits such as weight reduction, blood pressure control, and a reduced risk of cardiovascular events and kidney disease progression, making it a robust option for patients requiring more intensive therapy.
Uses
- Management of type 2 diabetes mellitus.
- When monotherapy with metformin or dapagliflozin is insufficient.
- Improvement of glycemic control.
- Reduction of cardiovascular and renal risks in type 2 diabetes.
Directions For Use
Take orally twice daily with meals to minimize gastrointestinal side effects, or as directed by your physician.
Benefits
- Provides comprehensive blood sugar control.
- Significantly reduces HbA1c levels.
- Promotes weight loss and blood pressure reduction.
- Reduces risk of major cardiovascular events.
- Slows the progression of chronic kidney disease.
- Combines two complementary mechanisms of action.
Side Effects
- Genital yeast infections
- Urinary tract infections
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Metallic taste
- Lactic acidosis (rare but serious)
- Vitamin B12 deficiency
- Hypoglycemia (less common with metformin alone)
- Headache
- Dizziness
Safety Measures
- Alcohol - Increases the risk of lactic acidosis (due to metformin) and dehydration/hypoglycemia (due to dapagliflozin). Avoid excessive intake.
- Pregnancy - Not recommended during pregnancy due to potential fetal harm and adverse effects on kidney development.
- Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk.
- Liver - Contraindicated in severe hepatic impairment due to increased risk of lactic acidosis with metformin.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to metformin accumulation and dapagliflozin ineffectiveness.
- Lung - Use with caution in conditions causing hypoxia (e.g., severe respiratory failure) as it may increase the risk of lactic acidosis.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
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| Shop Location | Assam, India |
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