Endace 40mg Tablet

About

Megestrol acetate is a synthetic progestin with significant anti-estrogenic properties, primarily utilized in the palliative treatment of advanced, recurrent, or metastatic breast and endometrial cancer. Its therapeutic action in oncology involves altering the hormonal environment, which can effectively inhibit the growth and progression of hormone-sensitive tumors. Beyond its antineoplastic effects, megestrol acetate is widely recognized for its potent appetite-stimulating properties. This makes it a valuable therapeutic agent in managing cachexia and significant, unexplained weight loss often associated with advanced cancer and AIDS. While the precise mechanism for appetite stimulation is not fully elucidated, it is believed to involve the modulation of cytokine production and metabolic pathways, leading to an improved nutritional status, increased body weight, and enhanced overall quality of life for patients experiencing severe wasting syndromes. It is an important component of supportive care in these challenging conditions.

Uses

• Palliative treatment of advanced breast cancer.
• Palliative treatment of advanced endometrial cancer.
• Management of anorexia, cachexia, or unexplained significant weight loss in AIDS patients.
• Management of significant weight loss in cancer patients.

Directions For Use

Take this medicine orally as directed by your doctor, usually once daily. Do not crush or chew the tablet; swallow it whole.

Benefits

• Helps manage advanced breast cancer.
• Effective in treating advanced endometrial cancer.
• Stimulates appetite in patients with cachexia.
• Aids in weight gain for patients with significant weight loss.
• Improves quality of life in palliative care.
• Available in convenient oral tablet form.

Side Effects

• Weight gain
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Rash
• Hot flashes
• Headache
• Insomnia
• Fluid retention
• Thromboembolic events
• Adrenal suppression

Safety Measures

• Alcohol - Alcohol consumption should be discussed with a doctor, as it may exacerbate some side effects or interact with the medication.
• Pregnancy - Contraindicated in pregnancy due to potential harm to the fetus. Effective contraception is required during treatment.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and affect the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary.
• Kidney - Use with caution in patients with kidney impairment; dose adjustment may be necessary.
• Lung - Generally safe for use in patients with lung conditions, but any pre-existing respiratory issues should be disclosed to the physician.

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