Endokine 300mcg Injection

About

Endokine 300mcg Injection contains Filgrastim, a synthetic form of human granulocyte colony-stimulating factor (G-CSF). This biological agent plays a critical role in hematopoiesis by stimulating the bone marrow to produce, mature, and release neutrophils, a type of white blood cell essential for fighting infections. Its primary therapeutic application is in managing neutropenia, a condition characterized by abnormally low neutrophil counts, which commonly occurs as a side effect of myelosuppressive chemotherapy.

By increasing neutrophil levels, Endokine 300mcg significantly reduces the risk of severe infections, including febrile neutropenia, which can be life-threatening for cancer patients. This allows for the continuation of chemotherapy regimens as planned, optimizing treatment outcomes. Beyond chemotherapy-induced neutropenia, Filgrastim is also indicated for other conditions such as severe chronic neutropenia, and for mobilizing hematopoietic stem cells into the peripheral blood for collection and subsequent transplantation. Its use requires careful monitoring of blood counts and patient response.

Uses

• Prevention of chemotherapy-induced neutropenia
• Treatment of severe chronic neutropenia
• Mobilization of peripheral blood progenitor cells
• Neutrophil recovery after bone marrow transplantation

Directions For Use

Administered via subcutaneous injection or intravenous infusion by a healthcare professional. Follow prescribed dosage and administration instructions.

Benefits

• Reduces the risk of serious infections
• Shortens the duration of neutropenia
• Allows for on-schedule chemotherapy treatments
• Improves quality of life for cancer patients
• Supports stem cell collection for transplantation
• Enhances immune system recovery

Side Effects

• Bone pain
• Fever
• Fatigue
• Headache
• Nausea
• Diarrhea
• Injection site reactions
• Splenomegaly (enlarged spleen)
• Allergic reactions
• Acute respiratory distress syndrome (rare)
• Capillary leak syndrome (rare)
• Thrombocytopenia (low platelet count)

Safety Measures

• Alcohol - No direct interaction is known, but general health advice to limit alcohol intake during medical treatment applies.
• Pregnancy - Use only if clearly needed and the potential benefits outweigh the risks. Consult a doctor, as animal studies show potential fetal harm.
• Breastfeeding - It is unknown if Filgrastim is excreted in human milk. Exercise caution and consult a doctor before breastfeeding.
• Liver - No specific dose adjustment is generally required for liver impairment, but monitor patient's overall condition.
• Kidney - No specific dose adjustment is generally required for kidney impairment, but monitor patient's overall condition.
• Lung - Rare cases of acute respiratory distress syndrome (ARDS) and pulmonary infiltrates have been reported. Monitor for new or worsening respiratory symptoms.

Disclaimer

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